局灶节段性肾小球硬化在IgA肾病中的发展机制

Mechanism of focal segmental glomerulosclerosis in IgA nephropathy

局灶节段性肾小球硬化(focal segmental glomerulosclerosis,FSGS)是一种常见的病理学病变,代表疾病进展的开始。FSGS对IgA肾病(IgA nephropathy,IgAN)的治疗与预后均有影响。IgAN是导致继发性FSGS的常见重要原因。FSGS可能继发于肾小球炎症或坏死的病变,也可能是足细胞损伤的结果。本文研究FSGS的病理分类以及IgAN的牛津分型,探讨二者对于的IgAN FSGS的临床及预后的预测。

Focal segmental glomerulosclerosis(FSGS)is a common pathological lesion that represents the onset of disease progression.FSGS has an impact on both treatment and prognosis in IgA nephropathy(IgAN).IgAN is a common and important cause of secondary FSGS.FSGS may be secondary to glomerular inflammation or necrosis,or it may be the result of podocyte injury.In this paper,we studied the pathological classification of FSGS and the Oxford classification of IgAN,and explored the clinical and prognostic predictions of IgAN FSGS.