特发性膜性肾病相关抗原的研究进展

Research progress in the related antigens of idiopathic membranous nephropathy

膜性肾病(membranous nephropathy,MN)是成人除糖尿病外致肾病综合征的主要原因,可分为特发性膜性肾病(idiopathic membranous nephropathy,IMN)和继发性膜性肾病(secondary membranousnephropathy,SMN),其中IMN占主要地位。MN组织病变的发病机制包括免疫复合物在肾小球沉积、补体激活和肾小管间质损伤。因发病机制不同,IMN和SMN在治疗上差别大,且经研究约一半MN患者预后不佳,因此明确诊断尤为重要。目前研究发现多种抗原在IMN的致病过程中发挥重要作用。

Membranous nephropathy(MN)is the main cause of nephrotic syndrome in adults other than diabetes.It can be divided into idiopathic membranous nephropathy(IMN)and secondary membranous nephropathy(IMN)and the IMN is dominant.The pathogenesis of MN tissue lesions includes immune complexes in glomerular deposition,complement activation,and tubulointerstitial damage.Because of the different pathogenesis,IMN and SMN are very different in treatment,and studies have shown that about half of MN patients have a poor prognosis,so it is particularly important to confirm the diagnosis.At present,a variety of antigens have been found to play an important role in the pathogenesis of IMN,and such antigens have been studied as hotspots.