清肠止痢汤和艾灸辅助治疗溃疡性结肠炎的效果及对炎症因子的影响

Effects of Qingchang zhili soup and moxibustion on ulcerative colitis and inflammatory factors

目的:探究清肠止痢汤和艾灸辅助美沙拉嗪治疗溃疡性结肠炎的疗效及对炎症因子的影响。方法:选取温州市中医院2016年7月至2018年3月间诊断及治疗的溃疡性结肠炎患者110例,采用随机数表法分为联合治疗组(55例)和对照组(55例),对照组采用美沙拉嗪治疗,0.8 g,3次/d,口服,联合治疗组在此基础上予以清肠止痢汤,100 mL,1次/d,口服,及艾灸治疗,30 min/d,疗程均为2周。比较2组患者治疗前后的临床疗效、中医证候积分、改良Mayo活动指数、Baron内镜分级评分、炎症因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)],以及药物不良反应情况。结果:联合治疗组的临床治疗总有效率明显高于对照组(χ~2=6.111,P=0.013),治疗前两组中医证候积分无明显差异(P>0.05),治疗后两组均显著下降(P<0.05),其中联合治疗组的证候积分显著小于对照组(P<0.05);治疗前两组患者的Mayo活动指数与Baron内镜分级评分均无明显差异(P>0.05)。治疗后两组患者的上述指标均显著下降(P<0.05),其中联合治疗组显著小于对照组(t=-17.407,-13.671;P=0.000,P=0.000);治疗前两组TNF-α、IL-6、IL-8水平无显著差异(P>0.05);治疗后两组上述指标均显著下降(P<0.05),其中联合治疗组治疗后各炎症因子水平显著低于对照组(t=-19.611,-7.391,-5.404;P=0.000,P=0.000,P=0.000);两组不良反应总发生率无显著差异(7.27%vs.14.55%;χ~2=0.842,P=0.359)。结论:清肠止痢汤和艾灸辅助美沙拉嗪治疗溃疡性结肠炎的疗效肯定,且能更好控制肠道黏膜炎症及体内炎症因子水平。

AIM:To expolre the effect of Qingchang zhili soup and moxibustion on ulcerative colitis and inflammatory factors.METHODS:From July 2016 to May 2017,a total of 110 patients with ulcerative colitis in our hospital were randomly divided into combined treatment group(55 cases)and control group(55 cases),the control group was treated with methalazine,0.8 g,3 times/d,and the combined treatment group received extra Qingchang zhili soup,100 mL,1 time/d and moxibustion,30 min/d,the course of treatment were 2 weeks.The curative effect,TCM syndrome scoring,the Improve Mayo activity index,Baron endoscopy grading,inflammatory cytokines including tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-8(IL-8)before and after treatment were compared,the adverse reactions during the treatment were also recorded and compared.RESULTS:The total effective rate of the combined treatment group was significantly higher than that of the control group(χ^2=6.111,P=0.013).There was no significant difference in TCM syndrome score between the two groups before treatment(P>0.05),both groups decreased significantly after treatment(P<0.05),the syndrome score of the combined treatment group was significantly lower than control group(P<0.05).There was no significant difference in Improve Mayo activity index and Baron endoscopy grading between the two groups before treatment(P>0.05),they were significantly reduced in both groups after treatment(P<0.05),the scores in combined treatment group were significantly lower than those of the control group(t=-17.407,-13.671;P=0.000,P=0.000).There was no significant difference in levels of TNF-α,IL-6,IL-8 between the two groups before treatment(P>0.05),they were significantly reduced in both groups after treatment(P<0.05),the levels in combined treatment group were significantly lower than the control group(t=-19.611,-7.391,-5.404;P=0.000,P=0.000,P=0.000).There was no significant difference in incidence of adverse reactions between the two groups(7.27%vs.14.55%;χ^2=0.842,P=0.359).CONCLUSION:The efficacy of Qingchang zhili soup and moxibustion in the treatment of ulcerative colitis is positive;it can better control the intestinal mucosal inflammation and inflammatory factor levels.