AECOPD患者PARC/CCL18、hs-CRP水平变化分析

Analysis on the changes of PARC/CCL18 and hs-CRP in AECOPD patients

目的探讨在慢性阻塞性肺疾病急性加重(AECOPD)患者的血清中肺部活化调节趋化因子/趋化因子配体18(PARC/CCL18)、超敏C反应蛋白(hs-CRP)的水平变化及临床意义。方法选择2017年9月至2018年3月在本院呼吸内科住院治疗的AECOPD患者65例为AECOPD治疗前组,根据血气分析结果分为2个亚组:不伴Ⅱ型呼吸衰竭31例,伴Ⅱ型呼吸衰竭34例;所有研究对象经治疗好转后为AECOPD治疗后组;同期健康查体示肺功能正常的35例为对照组。检测AECOPD组治疗前后、对照组血清PARC/CCL18、hs-CRP水平变化。结果 AECOPD组血清PARC/CCL18、hs-CRP水平均高于对照组(P<0.05);AECOPD组治疗后血清PARC/CCL18、hs-CRP水平均低于治疗前(P<0.05);AECOPD伴有呼吸衰竭组治疗前、后血清PARC/CCL18、hs-CRP水平均高于不伴有呼吸衰竭组(P<0.05);AECOPD组血清PARC/CCL18、hs-CRP水平具有正相关性(r=0.471,P=0.015)。结论 AECOPD患者血清PARC/CCL18、hs-CRP水平显著增高,且与患者病情严重程度呈正相关。

Objective To investigate the level and clinical significance of PARC/CCL18 and hsCRP in the acute exacerbation of AECOPD.Methods A total of 65 patients with AECOPD who were hospitalized in the respiratory department of our hospital from September 2017 to March2018 were selected as the AECOPD group.According to the blood gas analysis results,they were divided into two groups:without respiratory failure(n=31)and with respiratory failure(n=34).The changes of serum levels of PARC/CCL18 and hs-CRP before and after treatment in AECOPD group and control group were compared.Results The serum levels of PARC/CCL18 and hs-CRP were higher in the observation group than in the control group(P<0.05).In the AECOPD group,the two index were lower after treatment than before treatment(P<0.05).The serum levels of PARC/CCL18 and hs-CRP were higher in group with respiratory failure than those without(P<0.05).The serum levels of PARC/CCL18 and hs-CRP had a clear correlation in the AECOPD group(r=0.471,P=0.015).Conclusion The serum levels of PARC/CCL18 and hs-CRP of AECOPD patients increase significantly,and are positively correlated with the severity of clinical symptoms.