来曲唑与氯米芬治疗多囊卵巢综合征不孕效果对比分析

Comparison of letrozole and clomiphene citrate in the treatment of infertility due to polycystic ovary syndrome

目的探讨来曲唑与氯米芬在多囊卵巢综合征不孕治疗中的效果。方法选取本院2016年1月至2017年2月收治的100例多囊卵巢综合征不孕患者,随机分为来曲唑组和氯米芬组各50例,对比治疗效果。结果注射HCG日,来曲唑组的优势卵泡数目少于氯米芬组,但子宫内膜厚度和子宫颈黏液评分均高于氯米芬组,排卵率和妊娠率高于氯米芬组(P<0.05);来曲唑组的卵巢过度刺激综合征发生率和药物不良反应发生率均较氯米芬组低(P<0.05)。结论来曲唑在多囊卵巢综合征不孕患者促排卵治疗中倾向于单卵发育,促进排卵妊娠,对子宫内膜影响小,用药安全性高,值得推广。

Objective To explore the efficacy of letrozole and clomiphene citrate in the treatment of infertility due to polycystic ovary syndrome.Methods A total of 100 cases polycystic ovary syndrome(PCOS)infertile patients treated in our hospital in January 2016 to February 2017 were randomly divided into letrozole group and clomiphene group,with 50 cases in each group.The therapeutic effect was compared.Results The number of dominant follicles in letrozole group was less than that of clomiphene group,but the thickness of the endometrium and the cervical mucus score were higher than that in the clomiphene group.The ovulation rate and pregnancy rate in letrozole group were higher than those in the clomiphene group(P<0.05).The incidence of ovarian hyperstimulation syndrome and the incidence of adverse drug reactions in letrozole group were lower than those in clomiphene group(P<0.05).Conclusion The letrozole in the treatment of ovulation in patients with polycystic ovary syndrome is inclined to monozygotic development,promotes ovulation pregnancy,has little influence on endometrium.It is safe to use,and worth popularizing.