心理行为干预对肺癌化疗患者负性情绪及细胞免疫功能的影响

Effect of psychological behavior intervention on negative emotion and cellular immune function in the patients with lung cancer receiving chemotherapy

目的探讨心理行为干预对肺癌化疗患者负性情绪及细胞免疫功能的影响。方法选取2015年1月～2017年6月进行化疗治疗的肺癌患者共100例,随机分为干预组与对照组。对照组患者予以常规的治疗与干预措施,干预组患者在此治疗的基础上加用心理行为干预。分别在治疗前后评估患者的负性情绪,同时检测并比较两组患者的细胞免疫功能。结果干预8周后,两组患者SAS与SDS评分均较干预前明显下降(P<0.05或P<0.01),且干预组患者下降幅度较对照组更为明显(P<0.05);同时两组患者T淋巴细胞亚群CD_3^+和CD_4^+数值均较干预前升高(P<0.05或P<0.01),且干预组患者升高幅度大于对照组(P<0.05),而CD_8^+数值较干预前降低(P<0.05或P<0.01),且干预组患者降低幅度大于对照组(P<0.05)。结论心理行为干预可以有效减轻肺癌化疗患者抑郁、焦虑等负性情绪,改善患者机体的免疫功能。

Objective To investigate the effects of psychological behavior intervention on negative emotion and cellular immune function in the patients with lung cancer receiving chemotherapy. Methods A total of 100 patients with lung cancer who underwent chemotherapy from January 2015 to June 2017 were selected and randomly divided into intervention group and control group. Patients in the control group were given routine treatment and intervention measures. Patients in the intervention group were given psychological behavior intervention based on this treatment. The patient's negative emotions were evaluated before and after treatment respectively. At the same time, the cellular immune function was detected and compared between the two groups. Results After 8 weeks of intervention, the SAS and SDS scores of the two groups were significantly lower than those before the intervention(P<0.05 or P<0.01). The decrease of patients in the intervention group was more significant than that in the control group(P<0.05);at the same time, the CD3+ and CD4+ values of T lymphocyte subsets in the two groups were higher than those before intervention(P<0.05 or P<0.01), and the increase of patients in the intervention group was higher than that in the control group(P<0.05). The CD8+ value was lower than that before the intervention(P<0.05 or P<0.01), and the decrease of patients in the intervention group was greater than that in the control group(P<0.05). Conclusion Psychological behavior intervention can effectively alleviate negative emotions such as depression and anxiety in the patients with lung cancer receiving chemotherapy, and improve the immune function of patients.