阿奇霉素联合辛伐他汀对COPD伴肺动脉高压患者肺功能的影响

Effect of azithromycin combined with simvastatin on pulmonary function in COPD patients with pulmonary arterial hypertension

目的:探讨阿奇霉素联合辛伐他汀对COPD伴肺动脉高压患者肺功能的影响。方法:选取2016年4月～2018年4月我院收治的90例COPD伴肺动脉高压患者作为研究对象,将每位研究对象进行编号,按照抽签法的原则分成对照组和观察组,每组45例。对照组给予辛伐他汀药物治疗,观察组在对照组的基础上联合阿奇霉素治疗。分析两组治疗后的肺功能情况及血清总胆固醇、三酰甘油水平的变化,并对比不良反应发生率。结果:治疗后观察组FVC、FEV1高于对照组,血清总胆固醇、三酰甘油低于对照组,不良反应发生率(11.11%)低于对照组(28.89%),差异具有统计学意义(P<0.05)。结论:阿奇霉素联合辛伐他汀可以有效改善COPD伴肺动脉高压患者的肺功能情况,降低血清总胆固醇、三酰甘油的水平,减少不良反应发生情况,效果显著。

Objective:To investigate the effect of azithromycin combined with simvastatin on pulmonary function in chronic obstructive pulmonary disease(COPD) patients with pulmonary arterial hypertension (PAH). Methods:90 patients with COPD and PAH treated in the hospital from April 2016 to April 2018 were selected, and the each research object was given the number. All the patients were divided into control group and observation group by draw lots, with 45 cases in each group. Control group was given simvastatin, while observation group was treated with azithromycin based on control group. The pulmonary function after treatment, changes of total cholesterol, triglyceride in two groups were analyzed. The incidence of adverse reactions between the two groups were compared. Results:After treatment, the FVC and FEV1 of observation group were higher than those of control group, the total cholesterol and triglyceride in observation group were lower than control group, the incidence of adverse reactions in observation group(11.11%) was lower than control group(28.89%)(P<0.05). Conclusion:Azithromycin combined with simvastatin in treatment of COPD with PAH can effectively improve pulmonary function, decrease the levels of total cholesterol and triglyceride, reduce adverse reactions, which has significant effects.