儿童特应性皮炎严重程度与血清25-羟维生素D和总IgE水平的相关性

Relationship between clinical severity of atopic dermatitis in children and the levels of vitamin D and total IgE

目的:明确儿童特应性皮炎患者特应性皮炎严重程度与血清25-羟维生素D和IgE水平的相关性。方法:参考SCORAD评分法评估60例特应性皮炎患者疾病严重程度,并检测特应性皮炎患者及55例对照组血清25-羟基维生素D3水平以及特应性皮炎患者总IgE水平。结果:特应性皮炎组患者血清25-羟维生素D水平(16.13±6.68)ng/mL低于对照组(19.81±8.24)ng/mL,差异有统计学意义(P<0.05)。根据SCORAD评分,特应性皮炎患者中33例为轻度、20例为中度,7例为重度。轻度组血清25-羟基维生素D3水平为(18.69±7.01)ng/mL,高于中度(12.81±4.35)ng/mL,差异有统计学意义(P<0.05)。血清25-羟维生素D与SCORAD评分之间有显著负相关(P<0.05)。IgE水平与SCORAD评分之间无相关性(P>0.05)。结论:AD患者血清25-羟基维生素D与AD严重程度呈负相关。

Objective:To determine the correlation between the levels of serum vitamin D and IgE with the clinical severity of atopic dermatitis(AD)in children.Methods:The clinical severity of AD was evaluated with the SCORAD score.The levels of serum 25-hydroxide vitamin D3 and total IgE were detected in AD patients and 55 control subjects.Results:The level of vitamin D in AD group was 16.13±6.68ng/mL,which was lower than that in the control group(19.81±8.24 ng/mL),with a significant difference(P<0.05).According to the SCORAD score,the patients with AD were divided into three groups:mild group(33 cases),moderate group(20 cases)and severe group(7 cases).The level of vitamin D in mild group was 18.69±7.01 ng/mL,which was higher than that in the moderate group(12.81±4.35ng/mL),with a significant difference(P<0.05).There was a significant negative correlation between the level of vitamin D and the SCORAD score(P<0.05).There was no significant correlation between vitamin D and SCORAD score(P>0.05).Conclusion:Serum 25-hydroxyvitamin D3 level is negatively correlated with the severity of AD.