循环microRNA早期诊断肝细胞癌研究现状及方法学探讨

Serum microRNA in diagnosis of patients with hepatocellular carcinoma and methodological progress

肝细胞癌(HCC)是发病率和死亡率很高的恶性肿瘤,对高危人群的筛查和监测十分重要。定期检查肝脏超声和血清AFP是目前主要的筛查手段,但灵敏度和准确性仍不尽如人意。microRNA与HCC的发生、转移、复发等病理过程密切相关,相关研究也方兴未艾。循环microRNA是HCC血清学标志物中的重要成员,在HCC诊断和筛查方面具有广阔的应用前景。选择合适的microRNA和确定高效的诊断方法是相关研究的重点,更多高质量的研究还在持续进行中。

Hepatocellular carcinoma(HCC)is a malignant tumor with high morbidity and mortality.Screening and monitoring high risk population is very important.Routinely,the liver ultrasonography and serum AFP assay are the main screening methods at present,while the sensitivity and accuracy are not satisfactory.MicroRNAs(miRNAs)are closely related to the pathogenesis,metastasis and recurrence of HCC.Circulating miRNAs are important members of the serological biomarkers of HCC and have a broad prospect in the diagnosis and screening of HCC.The selection of appropriate miRNA and efficient diagnostic methods are the hot focus of related researches.