mNGF联合神经节苷脂治疗HIE对脑血流灌注及外周血S-100β Caspase3和mIL-2R表达的影响

Effects of mNGF combined with gangliosides on children with HIE and its influence on cerebral blood flow perfusion and expression levels of peripheral blood S-100β,Caspase3 and mIL-2R

目的探讨鼠神经生长因子(mNGF)联合神经节苷脂治疗缺氧缺血性脑病(HIE)的效果及对脑血流灌注、外周血S-100β、Caspase3和白介素-2受体(mIL-2R)表达的影响。方法选取郑州大学附属郑州中心医院2017-03—2018-02治疗的100例HIE患儿,随机分为观察组与对照组各50例,对照组给予神经节苷脂治疗,观察组在对照组的基础上联合使用mNGF,比较2组临床疗效、脑血流灌注水平以及外周血S-100β、Caspase3和mIL-2R表达水平。结果观察组临床有效率(90.00%)高于对照组(72.00%),差异有统计学意义(P<0.05);观察组治疗后颈内动脉收缩期流速(Vs)水平高于对照组,外周血管阻力(RI)水平较对照组低,差异有统计学意义(P<0.05);观察组治疗后S-100β、Caspase3水平低于对照组,外周血mIL-2R水平高于对照组,差异有统计学意义(P<0.05);2组治疗期间均未出现严重不良反应。结论 mNGF联合神经节苷脂治疗HIE,可有效改善患儿脑血流灌注水平以及外周血神经元蛋白指标,提高外周血中mIL-2R表达率,效果显著,安全性较高。

Objective To explore the effects of mouse nerve growth factor(mNGF)combined with gangliosides in the treatment of children with hypoxic ischemic encephalopathy(HIE)and its influence on cerebral blood flow perfusion and expression levels of peripheral blood S-100β,Caspase3 and mIL-2R.Methods 100 children patients with HIE from March 2017 to February 2018 were selected and randomly divided into observation group and control group,with 50 cases in each group.Control group was given gangliosides for treatment,and observation group was combined with mNGF on the basis of control group.The clinical efficacy,cerebral blood flow perfusion level and expression levels of peripheral blood S-100β,Caspase3 and interleukin 2 receptor(mIL-2R)were compared between the two groups.Results The clinical effective rate in observation group was higher than that in control group(90.00%vs 72.00%)(P<0.05).The systolic velocity(Vs)of internal carotid artery in observation group after treatment was higher than that in control group,and the peripheral vascular resistance(RI)level was lower than that in control group(P<0.05).The levels of S-100βand Caspase3 in observation group after treatment were lower than those in control group,and the peripheral blood mIL-2R level was higher than that in control group(P<0.05).There were no serious adverse reactions during treatment in the two groups.Conclusion mNGF combined with gangliosides for children with HIE can effectively improve the cerebral blood flow perfusion level and peripheral blood neuronal proteins levels,and increase the expression of mIL-2R in peripheral blood,and it has significant effects and high safety.