缺氧诱导因子-1α、葡萄糖转运蛋白-1和碳酸酐酶-Ⅸ在子宫内膜癌患者中的作用

Role of Hypoxia-inducible Factor-1α, Glucose Transporter-1 and Carbonic Anhydrase-Ⅸ in the Patients with Endometrial Cancer

目的探讨缺氧诱导因子-1α(HIF-1α)、葡萄糖转运蛋白-1(GLUT-1)和碳酸酐酶-Ⅸ(CA-Ⅸ)蛋白水平与子宫内膜癌患者的临床病理特征之间的关系。方法评估92例终末期子宫内膜癌患者的临床分期、组织学分级、侵犯子宫肌层深度、淋巴结转移、远处转移及存活时间;对子宫内膜癌组织切片进行免疫组化分析。结果统计学分析子宫内膜癌组织中HIF-1α、GLUT-1和CA-Ⅸ蛋白表达与其临床病理特征之间的关系后发现,HIF-1α的蛋白表达在子宫内膜癌的Bokhman亚型之间存在高度差异,HIF-1α的表达越高,复发的风险越高(P均>0.05)。结论 HIF-1α在高复发风险组和非子宫内膜样病理组织亚型的重要作用表明,该因子的表达可能有助于辅助病理形态学检查,并有助于子宫内膜癌患者更准确的预后判断。

Objective To study the relationship between the protein levels of hypoxia inducible factor-1α(HIF-1α),glucose transporter-1(GLUT-1)and carbonic anhydrase-Ⅸ(CA-Ⅸ)and the clinicopathological characteristics of patients with endometrial cancer.Methods The 92 patients with endometrial cancer were evaluated for clinical stage,histological grade,myometrial invasion,lymph node metastasis,distant metastasis and survival time.Immunohistochemical analysis was performed to analyze the endometrial cancer tissue.Results There was a significant difference between the protein expression of HIF-1αand the Bokhman subtypes of endometrial cancer;the higher the expression of HIF-1α,the higher the risk of recurrence(P<0.05).Conclusion The important role of HIF-1αin the high recurrence risk group and the negative histological subtypes suggests that the expression of HIF-1αmay be helpful in assisting pathomorphological examination and predicting the prognosis of patients with endometrial cancer.