壳聚糖-介孔二氧化硅复合材料的制备与止血性能研究

Synthesis and Hemostatic Properties Evaluation of Chitosan Mesoporous Silica Composites

目的研发一种具有快速且显著止血效果、优良生物相容性止血材料。方法通过介孔二氧化硅对壳聚糖进行改性,利用壳聚糖带正电而介孔二氧化硅带负电的特性,用烷基化壳聚糖负载介孔二氧化硅,制备新型止血材料。并通过材料表征实验、细胞毒性实验、吸水性能评价和体内外凝血实验评估其性能。结果新型止血材料在无细胞毒性的前提下有着更好的止血性能。结论壳聚糖-介孔二氧化硅复合材料是一种有着较好止血性能的材料。

Objective To develop a hemostatic material with rapid and significant hemostatic effect and excellent biocompatibility.Methods Mesoporous silica was used to modify chitosan.Chitosan was positively charged.Mesoporous silica was negatively charged,and mesoporous silica was loaded with alkylated chitosan to prepare novel hemostasis material.And through the material characterization experiments,cytotoxicity experiments,water absorption performance,we evaluated and in vitro and in vivo coagulation experiments to assess its performance.Results The novel hemostatic material had better hemostatic properties without cytotoxicity.Conclusion Chitosan-mesoporous silica composite is a material with good hemostatic properties.