IL-17、IL-6在狼疮性肾炎中的表达及与疾病活动度的关系

Expression of IL-17 and IL-6 in Lupus Nephritis and its Relationship with Disease Activity

目的探究白细胞介素-17(IL-17)和白细胞介素-6(IL-6)在狼疮性肾炎中的表达及与疾病活动度的相关性。方法选取笔者医院38例狼疮性肾炎患者和19例健康受试者作为正常对照组,采用酶联免疫吸附法检测受试者血清中IL-17和IL-6的表达水平,分析二者的相关性,并分析IL-17和IL-6与疾病活动度指标SLEDAI评分、活动指数(AI)和慢性指数(CI)的相关性。结果狼疮性肾炎静止期组和狼疮性肾炎活动期患者血清中IL-17、IL-6的表达水平显著高于正常对照组(P<0.05),活动期组显著高于静止期组(P<0.05),且IL-17与IL-6的表达水平呈显著正相关(r=0.436,P<0.05);狼疮性肾炎活动期组SLEDAI评分、AI、CI显著高于狼疮性肾炎静止期组(P<0.05),狼疮性肾炎患者血清中IL-17与SLEDAI评分、AI、CI呈正相关(r=0.406,P=0.002; r=0.377,P=0.000; r=0.405,P=0.001);狼疮性肾炎患者血清中IL-6与SLEDAI评分、AI、CI呈正相关(r=0.521,P=0.000; r=0.424,P=0.005; r=0.418,P=0.002)。结论狼疮性肾炎患者血清中IL-17和IL-6的表达水平呈显著正相关,且血清中IL-17和IL-6与疾病活动度指标SLEDAI评分、AI、CI呈正相关。

Objective To investigate the expression of interleukin-17(IL-17)and interleukin-6(IL-6)in lupus nephritis and its relationship with disease activity.Methods Thirty-eight patients with lupus nephritis were selected,and another nineteen health volunteers were selected as normal control group.The expression levels of serum IL-17 and IL-6 were detected by enzyme-linked immunosorbent assay(ELISA),and their correlation was analyzed.The correlations of IL-17 and IL-6 with disease activity index such as SLEDAI score,activity index(AI)and chronic index(CI)were analyzed.Results The expression levels of serum IL-17 and IL-6 were significantly higher in patients with lupus nephritis in stationary phase and active phase than those in normal control group(P<0.05).The expression levels of IL-17 and IL-6 in lupus nephritis active phase group were significantly higher than those in lupus nephritis stationary phase group(P<0.05).The expression level of IL-17 was positively correlated with the expression level of IL-6(r=0.436,P<0.05).The SLEDAI score,AI and CI in the active phase group of lupus nephritis were significantly higher than those in the stationary phase group of lupus nephritis(P<0.05).The serum IL-17 was positively correlated with SLEDAI score.AI and CI in patients with lupus nephritis(r=0.432,P=0.002;r=0.463,P=0.000;r=0.421,P=0.001).The serum IL-6 was positively correlated with SLEDAI score.AI and CI in patients with lupus nephritis(r=0.448,P=0.000;r=0.427,P=0.005;r=0.439,P=0.002).Conclusion The expression levels of serum IL-17 and IL-6 were positively correlated in patients with lupus nephritis,and the levels of serum IL-17 and IL-6 were positively correlated with disease activity index like SLEDAI score,AI and CI.