血清S100B蛋白对肺癌脑转移的诊断价值

Diagnostic Values of Serum S100B Protein for Lung Cancer with Brain Metastasis

目的检测肺癌脑转移患者血清S100B蛋白水平,探讨S100B作为肺癌脑转移相关血清标志物的可能性。方法采用ELISA分别检测111例肺癌脑转移患者(肺癌脑转移组)、62例肺癌未转移患者(肺癌无转移组)、33例肺癌其他部位转移患者(肺癌其他转移组)、38例健康体检者(健康对照组)血清S100B水平,应用SPSS19.0分析组间差异并制作ROC曲线。结果肺癌脑转移组S100B水平高于肺癌无转移组、其他转移组和健康对照组,差异有统计学意义(P<0.05);肺癌无转移组与其他转移组、健康对照组S100B水平差异无统计学意义(P>0.05)。S100B水平与病理分型、肿瘤年限、年龄、性别、吸烟史均无关(P>0.05)。S100B诊断肺癌脑转移的AUC为0.701,敏感度为45.0%,特异性为91.0%。结论肺癌脑转移患者血清S100B蛋白水平升高,S100B蛋白诊断肺癌脑转移具有一定的敏感度和较高的特异性,具有一定的临床价值,可以作为肺癌脑转移的血清标志物。

Objective To detect the levels the serum S100B protein in patients with brain metastasis of lung cancer,and explore the possibility of using S100B as a serum marker associated with brain metastasis of lung cancer.Methods The level of serum S100B protein was detected by ELISA respectively in 111 cases with brain metastasis of lung cancer(brain metastasis of lung cancer group),62 cases without metastasis of lung cancer(lung cancer without metastasis group),33 cases with metastasis of other parts of lung cancer(lung cancer with other parts metastasis group)and 38 healthy volunteers(control group).We analyzed the difference between the groups and made ROC Curve with SPSS19.0.Results(1)Brain metastasis of lung cancer group showed higher S100B protein level than the lung cancer without metastasis group,the lung cancer with other parts metastasis group and the healthy control group(P<0.05),but there were no significant changes in the lung cancer without metastasis group,the lung cancer with other parts metastasis group and the healthy control group(P>0.05).(2)S100B protein level was not related to pathological type,tumor age,age,sex and smoking history.(3)The measurement showed an AUC of 0.701.And the sensitivity and specificity of S100B protein in the diagnosis of brain metastasis of lung cancer were 45.0%and 91.0%,respectively.Conclusion Serum S100B protein was up-regulated in patients with brain metastasis of lung cancer and has a certain sensitivity and specificity in the diagnosis of brain metastasis of lung cancer.It has certain clinical value and can be used as a serum marker for brain metastasis of lung cancer.