血清肿瘤标志物CEA、CA125、CYFRA21-1在支气管肺癌诊断、病理类型及TNM分期中的价值分析

Clinical value of CEA,CA125 and CYFRA21-1 in the diagnosis,pathological types and TNM stages of lung cancer

目的探讨癌胚抗原(CEA)、糖类抗原(CA125)、细胞角蛋白19片段(CYFRA21-1)在肺癌诊断、病理类型及TNM分期中的应用价值。方法收集2017年1月至2018年4月入住唐都医院的288例患者的临床资料,采用电化学免疫荧光发光法检测血清肿瘤标志物的浓度,分析CEA、CA125、CYFRA21-1与肺癌诊断、病理类型及TNM分期的关系。结果肺癌组CEA、CA125、CYFRA21-1血清表达水平高于肺部良性病变组,P<0.05。单个肿瘤标志物在区分肺癌不同病理类型时,CYFRA21-1诊断价值最高。在肺癌不同TNM分期中,CEA、CA125阳性率随着肿瘤分期逐渐升高,各分期之间阳性率存在统计学意义,P<0.05。CYFRA21-1其阳性率随分期变化逐渐升高,但各组间无统计学意义,P>0.05。结论 CEA、CA125、CYFRA21-1在肺癌诊断价值中有意义,在不同病理类型中CYFRA21-1诊断价值较大,CEA、CA125、CYFRA21-1在肺癌TNM分期中诊断价值不同,利用血清肿瘤标志物进行TNM分期,可为病理TNM分期提供参考。

Objective To evaluate the application of CEA,CA125 and cytokeratin 19 fragments(CYFRA21-1)in the diagnosis,pathological types and TNM stages of lung cancer.Methods It was collected 288 cases of hospitalized patients clinical data in Tang Du hospitals between January 2017 and April 2018.The concentrations of tumor markers in serum were detected by electrochemical immunofluorescence.It was analyzed the relationship between CEA,CA125 and CYFRA21-1 which were about lung cancer diagnosis,pathological types and TNM stages.Results Serum levels of CEA,CA125 and CYFRA21-1 in the lung cancer group were higher than those in the benign lung lesions group.CYFRA21-1 is the most valuable single tumor marker in different pathological types of lung cancer.The positive rates and serum levels of CEA and CA125 were of high application value in different TNM stages of lung cancer.Serum levels of CEA,CA125 and CYFRA21-1 are of great value in the early and late differentiation of lung cancer.Conclusion The CEA,CA125 and CYFRA21-1 are significant in the diagnosis of lung cancer.Among different pathological types,CYFRA21-1 is of great diagnostic value.The CEA,CA125 and CYFRA21-1 have different diagnostic values in TNM stage of lung cancer.