TIM-3-574G>T基因多态性与中国汉族人群支气管哮喘的相关性分析

Association between-574G>T polymorphism of TIM-3 Gene and bronchial asthma in Chinese Han population: A meta analysis

目的采用Meta分析评价T细胞免疫球蛋白黏蛋白域蛋白-3 (TIM-3)-574 G> T(rs10515746)基因多态性与中国汉族人群支气管哮喘易感性的关系。方法检索中外文献数据库中TIM-3-574 G>T基因多态性与中国汉族人群支气管哮喘易感性关系的病例对照研究,末次检索时间为2017年12月20日。采用Rev Man 5.0对TIM-3-574 G>T基因多态性与哮喘易感的显性模型OR值进行合并、敏感性分析和亚组分析,以及采用Stata对纳入文献的发表偏倚情况进行评估。结果共纳入5篇文献,其中病例组患者1 241例,对照组患者1 005例。Meta分析显示中国汉族人中TIM-3-574 G>T基因上突变型GT者的支气管哮喘发病风险较野生型纯合子GG者增加3.06倍(OR=4.06,95%CI:2.34,7.05),携带突变基因T者患支气管哮喘的风险比携带野生型G基因者增加3.31倍(OR=4.31,95%CI:2.50,7.43)。亚组分析显示携带GT基因型的成人和儿童患病风险均较纯合子GG高(儿童组:OR=4.07,95%CI:1.62,10.20;成人组:OR=3.09,95%CI:1.40,6.85)。结论 T细胞免疫球蛋白黏蛋白域蛋白-3-574 G>T基因多态性与中国汉族人群支气管哮喘易感性有密切相关,突变T基因携带者患支气管哮喘的风险更高。

Objective We performed the Meta-analysis to better investigate the association between-574 G>T genetic polymorphism of T cells immunoglobulin domain and mucin domain protein-3(TIM-3) and bronchial asthma(asthma) susceptibility in Chinese Han population. Methods Eligible case-control studies were searched from Chinese National Knowledge Infrastructure(CNKI), WanFang Database, SinoMed, Pubmed, Embase and Web of Science up to December. 20th 2017. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the potential association between-574 G>T variant of TIM-3 gene and asthma in dominant model by RevMan 5.3. This software was also used to perform sensitivity analysis and subgroup analysis. Additionally, publish bias can be well assessed by Stata 12.0. Results A total of five articles containing 1 241 asthma patients and 1 005 control subjects were included in our study. The risk of developing asthma in Asian population carried GT genotype is 306% higher than those who carried GG wild-type( OR =4.06, 95% CI : 2.34,7.05). T allele carriers had a 331% increased risk to develop asthma compared with G allele carriers( OR =4.31, 95% CI : 2.50,7.43). The result of subgroup analysis showed that both adults and children with GT genotype were more vulnerable to asthma than GG wild-type carriers(children group: OR = 4.07 , 95% CI : 1.62, 10.20;adults group: OR =3.09, 95% CI : 1.40, 6.85). Conclusions TIM-3-574 G>T polymorphism was associated with asthma susceptibility in Chinese Han population. T allele carriers had higher risk to develop asthma than wild-type carriers.