补肾和脉方加减对中老年单纯收缩期高血压病患者管壁僵硬度的影响

Effect of Bushen Hemai decoction on vascular stiffness in elderly patients with isolated systolic hypertension

目的:探讨中老年单纯收缩期高血压患者应用补肾和脉方加减治疗疗效以及对患者管壁僵硬度的影响。方法:按照随机表法将收治的126例中老年单纯收缩期高血压患者分为对照组63例与观察组63例。对照组采用常规西药治疗,观察组在对照组基础上结合补肾和脉方甲减治疗。两组疗程均为4周。比较两组治疗前后收缩压和舒张压变化、心电图ST段水平变化和脉搏传导速度变化及治疗疗效。结果:两组治疗后收缩压较治疗前降低(观察组:t=16.165,对照组:t=13.537,P<0.05);两组治疗后收缩压较治疗前无明显变化(观察组:t=1.857,对照组:t=0.483,P>0.05);观察组治疗后收缩压低于对照组(t=16.165,P<0.05)。两组治疗后心电图ST段水平较治疗前降低(观察组:t=22.145,对照组:t=11.007,P<0.05);观察组治疗后心电图ST段水平低于对照组(t=8.130,P<0.05)。两组治疗后脉搏传导速度较治疗前降低(观察组:t=8.694,对照组:t=3.944,P<0.05);观察组治疗后脉搏传导速度低于对照组(t=5.326,P<0.05)。观察组总有效率(93.65%)高于对照组(76.19%)(P<0.05)。结论:中老年单纯收缩期高血压患者应用补肾和脉方加减治疗疗效明显,且可使患者管壁僵硬度得以改善。

Objective:To investigate the effect of Bushen Hemai decoction on the wall stiffness of middle-aged and elderly patients with simple systolic hypertension.Methods:The 126 middle-aged and elderly patients with simple systolic hypertension admitted to our hospital from May 2010 to May 2015 were randomly divided into control group(63 cases)and observation group(63 cases).The control group was treated with conventional Western medicine,while the observation group was treated with Bushen Hemai decoction on the basis of the control group.The two groups were treated for 4 weeks.Results:The systolic blood pressure of the two groups decreased after treatment(observation group:t=16.165,control group:t=13.537,P<0.05);the systolic blood pressure of the two groups did not change significantly after treatment(observation group:t=1.857,control group:t=0.483,P>0.05);the systolic blood pressure of the observation group was lower than that of the control group after treatment(t=16.165,P<0.05).After treatment,the level of ST segment of ECG in the two groups was lower than that before treatment(observation group:t=22.145,control group:t=11.007,P<0.05);after treatment,the level of ST segment of ECG in the observation group was lower than that in the control group(t=8.130,P<0.05).After treatment,the pulse conduction velocity of the two groups was lower than that of the control group(observation group:t=8.694,control group:t=3.944,P<0.05);after treatment,the pulse conduction velocity of the observation group was lower than that of the control group(t=5.326,P<0.05).The total effective rate of the observation group(93.65%)was higher than that of the control group(76.19%)(P<0.05).Conclusion:Bushen Hemai Decoction has a significant clinical effect on middle-aged and elderly patients with simple systolic hypertension,and can improve the stiffness of the tube wall,which is worthy of clinical reference.