人类疱疹病毒(EBV)与消化性溃疡的相关性研究

Study on th correlation between EB virus and peptic ulcer

目的研究人类疱疹病毒(Epstein-Barr virus,EBV)感染和消化性溃疡(peptic ulcer disease,PUD)之间的关系。方法选取川北医学院附属医院PUD患者58例为PUD组,另选取95名健康人为健康对照组,其中包括43例十二指肠溃疡和15例胃溃疡,检测血清中的EBV活化抗原、Hp抗体以及Hp毒力因子CagA的含量。结果高滴度的抗EBV抗体IgG与发生十二指肠溃疡之间存在明显的相关性(P=0.022,OR=2.5);抗EBV抗体IGA阳性与胃溃疡发生相关(P=0.002,OR=10.1)。结论 EBV活化会增加胃和十二指肠上皮发生PUD的风险。

Objective To investigate the correlation between Epstein-Barr virus(EBV)infection and peptic ulcer disease(PUD).Methods A total of 153 Han Chinese subjects were included in the study,including the control group(healthy person,n=95),PUD group(n=58,43 cases of duodenal ulcer and 15 cases of gastric ulcer).The EBV activating antigen,Hp antibody,and Hp virulence factor CagA in serum were detected.Results There was a significant correlation between high titer anti-EBV antibody IgG and duodenal ulcer(P=0.022,OR=2.5),while anti-EBV antibody IGA positive was associated with gastric ulcer(P=0.002,OR=10.1).Conclusion Our research suggests that EBV activation increases the risk of PUD in the gastric and duodenal epithelium.