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不同剂量胰岛素联合电解质补充治疗小儿糖尿病酮症酸中毒的效果分析 被引量:8

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摘要 目的探讨不同剂量胰岛素联合电解质补充治疗小儿糖尿病酮症酸中毒的效果。方法选取2017年3月—2018年6月间该院收治的糖尿病合并酮症酸中毒患儿共72例,将其以数字随机表法的分组形式均分为实验组及对照组,每组36例。两组患儿均给予电解质补充治疗,实验组在此基础上联合低剂量胰岛素进行治疗,对照组在此基础上联合高剂量胰岛素进行治疗,对比观察两组患儿治疗有效率、血糖降低速度、尿酮体转阴时间、餐后2 h空腹血糖、肌酐、尿素氮、CO2Cp及低血糖出现情况等指标。结果实验组患儿治疗有效率(88.9%)明显高于对照组患儿(72.2%),差异有统计学意义(P<0.05);实验组患者血糖降低速度及空腹血糖明显低于对照组患者,差异有统计学意义(P<0.05),两组患儿酮体转阴时间对比差异无统计学意义(P>0.05);治疗后实验组患儿肌酐及尿素氮明显低于对照组患儿,CO2Cp水平明显高于对照组患儿,差异有统计学意义(P<0.05);实验组患儿低血糖出现率明显低于对照组患儿,差异有统计学意义(P<0.05)。结论使用低剂量胰岛素联合电解质补充治疗糖尿病合并酮症酸中毒患儿疗效显著,可纠正患儿体内电解质紊乱,减少低血糖发生,更为安全有效,值得于临床中进一步推广使用。
出处 《糖尿病新世界》 2019年第2期178-179,共2页 Diabetes New World Magazine
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  • 1谢锦桃,刘军,周盛鹏,朱素君,冷爱文.美国糖尿病协会2009糖尿病诊疗指南解读[J].中国全科医学,2009,12(14):1255-1257. 被引量:82
  • 2FULD K,CONRAD B,BUCKINGHAM B,et al.Insulin pumps in young children[J].Diabetes Technol Ther,2010,12(1):S67-S71.
  • 3GLASER N.New perspectives on the pathogenesis of cerebral edema complicating diabetic ketoacidosis in children[J].Pediatr Endocrinol Rev,2006,3(4):3792-3861.
  • 4KAPELLEN T M,HEIDTMANN B,BACHMANN J,et al.Indications for insulin pump therapy in different age groups:an analysis of 1567 children and adolescents[J].Diabet Med,2007,24(8):836-842.
  • 5BERGHAEUSER M A,KAPELLEN T,HEIDTMANN B,et al.Continuous subcutaneous insulin infusion in toddlers starting at diagnosis of type 1 diabetes mellitus.A multicenter analysis of 104 patients from 63 centres in Germany and Austria[J].Pediatr Diabetes,2008,9(6):590-595.
  • 6NABHAN Z M,KREHER N C,GREENE D M,et al.A randomized prospective study of insulin pump vs.insulin injection therapy in very young children with type 1 diabetes:12-month glycemic,BMI,and neurocognitive outcomes[J].Pediatr Diabetes,2009,10(3):202-208.
  • 7RABBONE I,BOBBIO A,DI GIANNI V,et al.Intensive insulin therapy in preschool-aged diabetic children:from multiple daily injections to continuous subcutaneous insulin infusion through indwelling catheters[J].J Endocrinol Invest,2008,31(3):193-195.
  • 8RABBONE I,SCARAMUZZA A,BOBBIO A,et al.Insulin pump therapy management in very young children with type 1 diabetes using continuous subcutaneous insulin infusion[J].Diabetes Technol Ther,2009,11(11):707-709.
  • 9MULLER GODEFFROY E,TREICHEL S,WAGNER V M,et al.Investigation of quality of life and family burden issues during insulin pump therapy in children with Type 1 diabetes mellitus a large-scale multicentre pilot study[J].Diabetic Medicine,2009,26(5):493-501.
  • 10SULMONT V,SOUCHON P F,GOUILLARD DARNAUD C,et al.Metabolic control in children with diabetes mellitus who are younger than 6 years at diagnosis:continuous subcutaneous insulin infusion as a first line treatment?[J].J Pediatr,2010,157(1):103-107.

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