二甲双胍联合维格列汀治疗2型糖尿病的效果观察

Effect of Metformin Combined with Vildagliptin for the Treatment of Type 2 Diabetes Mellitus

目的探讨二甲双胍联合维格列汀治疗2型糖尿病的效果。方法选取我院2015年1月至2018年1月间收治的120例2型糖尿病患者为研究对象,根据治疗方式的不同分为两组各60例。对照组给予二甲双胍治疗,观察组给予二甲双胍联合维格列汀治疗,比较两组的治疗效果。结果观察组患者的治疗总有效率为95.0%,显著高于对照组的80.0%(P <0.05)。治疗后,观察组患者的空腹血糖、餐后2 h血糖和糖化血红蛋白水平,以及TNF-α、 IL-6、 CRP水平均显著优于对照组患者(P <0.05)。结论二甲双胍联合维格列汀治疗2型糖尿病的效果显著,可有效改善患者的血糖水平和炎性因子水平,值得临床推广应用。

Objective To explore the effect of metformin combined with vildagliptin for the treatment of type 2 diabetes mellitus (T2DM). Methods 120 cases of patients with T2DM admitted to our hospital from January 2015 to January 2018 were selected as research objects. All cases were divided into two groups equally according to the treatment methods. The control group was treated with metformin, while the observation group was treated with metformin combined with vildagliptin. The curative effects of the two groups were compared. Results The total effective rate of treatment of the observation group was 95.0%, significantly higher than 80.0% of the control group (P <0.05). After treatment, the levels of fasting blood glucose, 2 h postprandial blood glucose and glycated hemoglobin, as well as the levels of TNF-琢, IL-6 and CRP of the observation group were significantly better than those of the control group (P <0.05). Conclusions Metformin combined with vildagliptin for the treatment of type 2 diabetes mellitus has significant effect, which can effectively improve the levels of blood glucose and inflammatory factors, and is worthy of clinical promotion and application.