胃肠道恶性肿瘤患者肿瘤复发相关因子PGE2、IL-2的水平及其与临床特征的关系

Level of tumor recurrence related factors PGE2 and IL-2 in patients with gastrointestinal malignancy and the correlation with clinical manifestations

目的探讨胃肠道恶性肿瘤患者肿瘤复发相关因子前列腺素E2(PGE2)、白细胞介素-2(IL-2)的水平及其与性别、肿瘤大小、围手术期输血量及输血类型的关系。方法回顾性分析246例胃肠道恶性肿瘤患者的病历资料。所有患者均行胃肠道肿瘤根治术,且术前经胃肠镜病理检查确诊。分别在术前1天、术后3天抽取外周血检测PGE2、IL-2水平,并分析不同性别、肿瘤大小、围手术期输血量、输血类型患者的PGE2、IL-2水平。结果术前1天、术后3天,不同性别、肿瘤大小、围手术期输血量、输血类型的胃肠道恶性肿瘤患者的PGE2、IL-2水平比较,差异均无统计学意义(P﹥0.05)。结论不同性别、肿瘤大小、围手术期输血量、输血类型的胃肠道恶性肿瘤患者短期内肿瘤复发相关因子PGE2、IL-2水平变化不大。

Objective To investigate the level of tumor recurrence related factors prostaglandin E2 (PGE2), serum interleukin- 2 (IL-2), and their relationship with gender, tumor size and perioperative blood transfusion volume and type in patients with gastrointestinal malignancy. Method A retrospective analysis including the clinical profiles of 246 patients with gastrointestinal malignancy was performed. All patients were given radical resection of gastrointestinal tumor, before which the lesions were confirmed by gastroscopy and pathology. The level of PGE2 and IL-2 were detected in peripheral blood collected in 1 d before surgery and 3 d after surgery from these subjects, respectively, the relationship between gender, tumor size, perioperative blood transfusion volume, blood transfusion type and the level of PGE2 and IL-2 were analyzed. Result In 1 d before surgery and 3 d after surgery, the level of PGE2 and IL-2 in patients with different gender, tumor size, perioperative blood transfusion volume and blood transfusion type were of no statistically significant differences (P>0.05). Conclusion Gender, tumor size, perioperative blood transfusion volume and blood transfusion type in gastrointestinal malignancy patients are not necessarily associated with the level of tumor recurrence related factors PGE2 and IL-2 in short term after operation.