肿瘤新抗原在恶性肿瘤治疗和预后分析中的应用

Application of neoantigens in malignant tumor treatment and prognosis evaluation

近年来随着二代测序技术,特别是全外显子测序和生物信息技术的进步,肿瘤的精准免疫治疗得到了很大发展;肿瘤新抗原的研究更是为肿瘤的免疫治疗提供了新的研究方向.本文基于近十年来关于肿瘤新抗原的研究,系统介绍精准医疗时代肿瘤新抗原在恶性肿瘤治疗上的作用和可能的应用,以及肿瘤新抗原研究中可能遇到的挑战.

In the last decade,there have been an endless number of cancer therapy strategies,and the study of tumor neoantigens provides a new direction for cancer immune therapy.With the development of deep sequencing,especially whole-exome sequencing,great opportunities have been provided to precise immune therapy of malignant tumors.This article systematically summarizes the research on tumor neoantigens in the past ten years and the challenges most likely to be encountered,describes the role of neoantigens in the treatment of malignant tumors,and discusses their possible clinical applications.