COL6A3基因在胃癌中的表达及临床意义

Clinical significance of COL6A3 expression in gastric cancer

背景从分子水平探析胃癌(gastric cancer, GC)病理机制对改善患者预后至关重要.目前, COL6A3在GC中的表达情况及临床意义鲜有报道.目的研究COL6A3基因在GC中的表达情况和临床意义,并探究可能的作用机制.方法收集GC相关生物大数据,对肿瘤样本的基因表达谱数据及其对应的临床信息进行回顾性分析和生存分析;采用基因集富集分析方法探讨COL6A3在GC中可能的作用机制.结果 COL6A3在GC中表达明显升高(P <0.0001),且具有较大诊断价值(AUC=0.9516). COL6A3高表达与T分期显著相关(P=0.001), COL6A3高表达的GC浸润深度更大. COL6A3高表达患者的预后明显差于低表达患者(P=0.0018). COL6A3高表达样本中,富集了多个肿瘤相关通路的基因集(n=68).结论 COL6A3高表达与GC的发生发展相关,具有较大的临床意义.

BACKGROUND Elucidating the molecular mechanism of gastric cancer(GC)is of great significance,especially for improving the prognosis,and few studies have focused on the clinical significance of COL6A3 expression in GC.AIM To analyze the clinical significance of COL6A3 expression in GC,and to identify the potential role of COL6A3 in GC.METHODS The biological big data of GC were collected,and retrospective analysis and survival analysis were conducted on the expression profile of COL6A3 in tumor samples and its relationship with clinical data.Gene set enrichment analysis was used to identify the potential role of COL6A3 in GC.RESULTS COL6A3 was highly expressed in GC(P<0.0001)with good diagnostic value(AUC=0.9516).High COL6A3 expression was associated with deeper tumor invasion(P=0.001).Patients with high expression of COL6A3 showed a poorer prognosis than those with low expression(P=0.0018).The tumor-related gene sets were enriched in the samples with high COL6A3 expression.CONCLUSION The high expression of COL6A3 is related to the occurrence and development of GC.