HMGB1/TLRs/MyD88信号通路与神经病理性痛

HMGB1/TLRs/MyD88 signaling pathway and neuropathic pain

HMGB1/TLRs/MyD88信号转导通路是生物体内重要的信号通路之一,在免疫功能调节中发挥着重要作用。近年来有研究表明,HMGB1/TLRs/MyD88信号转导通路激活后可诱导和维持不同条件下的痛敏反应,参与神经病理性痛的发生、发展过程。随着在细胞、分子水平对这一信号通路参与神经病理性痛的机制研究,将为神经病理性痛的临床治疗提供新靶点和理论依据。

HMGB1/TLRs/MyD88 signaling pathway is one of the important signaling pathways in vivo and plays a key role in the regulation of innate immune response.Recent studies have shown that the activation of HMGB1/TLRs/MyD88 signaling pathway can induce and maintain hyperalgesia under different conditions,and participate in the occurrence and development of neuropathic pain.With the study for the mechanism of this signaling pathway involving in neuropathic pain at the cellular and molecular level,it will provide a new target and theoretical basis for the clinical treatment of neuropathic pain.