摘要
炎症小体是存在于细胞质的多蛋白质复合物,参与机体的固有免疫反应,活化促炎因子白细胞介素-1β等介导了细胞的死亡,对炎症的进程有重要的调控作用。牙周炎是由多种牙周病致病菌(例如牙龈卟啉单胞菌)引起的炎性破坏性疾病。细菌菌体以及其毒性成分可以引发多种炎症小体的聚集组装,最终导致牙周组织的破坏等变化。本文将就机体发生牙周炎过程中炎症小体的产生和致病机制进行综述。
Inflammasome is a multi-protein complex that exists in the cytoplasm and is involved in innate immune response. This multi-protein oligomer can activate proinflammatory cytokines such as interleukin-1β, mediate cell death, and regulate the progression of inflammation. Periodontitis is an inflammatory and destructive disease caused by various periodontal pathogens, such as Porphyromonas gingivalis. Bacteria and their toxic components can cause the assembly of various inflammasomes and eventually destroy periodontal tissues. This review focuses on the production of inflammasomes in periodontitis and its mechanism of causing diseases.
作者
吕慧欣
杜留熠
王鹞
于维先
任静宜
顾芯铭
周延民
LU Huixin;Du Liuyi;Wang Yao;Yu Weixian;Ren Jingyi;Gu Xinming;Zhou Yanmin(Implant Center, Hospital of Stomatology, Jilin University, Changchun 130021, China;Key Laboratory of Mechanism of Tooth Development and Jaw Bone Remodeling and Regeneration in Jilin Province, Changchun 130021, China)
出处
《国际口腔医学杂志》
CAS
CSCD
2019年第2期186-190,共5页
International Journal of Stomatology
基金
国家自然科学基金(81570983)
吉林大学研究生创新基金资助项目(2017014)~~