炎症小体在牙周炎中的研究进展

Research progress on inflammasome in periodontitis

炎症小体是存在于细胞质的多蛋白质复合物,参与机体的固有免疫反应,活化促炎因子白细胞介素-1β等介导了细胞的死亡,对炎症的进程有重要的调控作用。牙周炎是由多种牙周病致病菌(例如牙龈卟啉单胞菌)引起的炎性破坏性疾病。细菌菌体以及其毒性成分可以引发多种炎症小体的聚集组装,最终导致牙周组织的破坏等变化。本文将就机体发生牙周炎过程中炎症小体的产生和致病机制进行综述。

Inflammasome is a multi-protein complex that exists in the cytoplasm and is involved in innate immune response. This multi-protein oligomer can activate proinflammatory cytokines such as interleukin-1β, mediate cell death, and regulate the progression of inflammation. Periodontitis is an inflammatory and destructive disease caused by various periodontal pathogens, such as Porphyromonas gingivalis. Bacteria and their toxic components can cause the assembly of various inflammasomes and eventually destroy periodontal tissues. This review focuses on the production of inflammasomes in periodontitis and its mechanism of causing diseases.