与牙周炎相关的组织蛋白酶研究进展

Research progress on cathepsins related to periodontitis

组织蛋白酶是溶酶体中的蛋白质水解酶,在全身疾病(如肿瘤、骨质疏松症、类风湿性关节炎)中的致病作用是当今的研究热点,有大量研究表明其与牙周炎的发生、发展密切相关。组织蛋白酶对于牙周炎的研究以及临床预防和减轻牙周炎具有重要意义。本文就与牙周炎相关的组织蛋白酶K、B、C、G的结构与功能、致病机制及相关抑制剂进行综述。

Cathepsin series, also known as proteolysis enzymes in the lysosome, have received attention for their pathology in systemic diseases such as tumour, osteoporosis and rheumatoid arthritis. Many studies have shown that cathepsins are also closely related to the occurrence and progression of periodontitis. Therefore, research on cathepsins towards clinical precaution and alleviation of periodontitis is of great importance. This article reviews the structures, functions, pathogenesis and relevant inhibitors of cathepsins K, B, C and G which are associated with periodontitis.