崔学教治疗肾精亏损型弱精子症用药规律研究

Study on Medication Rules of CUI Xuejiao in Treating Asthenospermia with Kidney Essence Deficiency Type

目的分析崔学教教授治疗肾精亏损型弱精子症的用药特点,探讨其用药规律。方法收集2017年6月1日-2017年11月30日崔教授于广州中医药大学第一附属医院外科(男科)门诊诊治的肾精亏损型弱精子症病案数据。运用SPSS19.0统计软件,采用频数分析、因子分析、聚类分析等统计方法进行数据挖掘。结果纳入病例247例、328诊次,剔除未使用中药91诊次,最终纳入处方237首,涉及药物75味,共计3071次。高频药物前5位是菟丝子(236次)、桑葚(236次)、覆盆子(226次)、淫羊藿(208次)、巴戟天(198次)。药物药性以平、温性,甘、苦味为主;主要归肝、肾经;多为补益之品(补阳药、补阴药、补气药)。挖掘得到9个公因子,均呈现出补益肾阳、健脾益气、补益气血等治法特点;聚类分析发现五子衍宗丸这一基础方。结论崔教授治疗肾精亏损型弱精子症用药规律体现了其以益肾为主的治疗原则,根据辨证配合使用收敛药、清热药等,补中有清、阴阳调和、标本兼治。

Objective To analyze the characteristics of medication in the treatment of asthenospermia in patients with kidney essence deficiency type by Professor CUI Xuejiao;To discuss the medication rules. Methods Data from asthenospermia in patients with kidney essence deficiency type treated by Prof. CUI in the department of surgery (male) of the First Affiliated Hospital of Guangzhou University of Chinese Medicine from June 1st, 2017 to November 30th, 2017 were collected. SPSS19.0 statistical software was used, and data mining was carried out by using statistical methods such as frequency analysis, factor analysis and cluster analysis. Results Totally 247 medical cases and 328 times of visits were included, and 91 times of visits without using Chinese materia medica were excluded, so finally 237 prescriptions were included, involving 75 kinds of Chinese materia medica and the total medication frequency was 3071. The first five high-frequency Chinese materia medica were Cuscutae Semen (236 times), Mori Fructus (236 times), Rubi Fructus (226 times), Epimedii Folium (208 times) and Morindae Officinalis Radix (198 times). The properties of high-frequency Chinese materia medica were mainly to be flat and warm, sweet and bitter. The high-frequency Chinese materia medica were mainly for liver and kidney meridians, most of them were tonifying medicines (tonifying yang medicine, tonifying yin medicine and tonifying qi medicine). Nine common factors were found through data mining, which showed the characteristics of invigorating kidney-yang, tonifying spleen and replenishing qi, invigorating qi and blood, etc. Cluster analysis found a basic prescription which called Wuzi Yanzong Pills. Conclusion The therapeutic principle of Prof. CUI in treating asthenospermia with kidney essence deficiency type is replenishing kidney essence, using astringent medicine and heat-clearing medicine according to syndrome differentiation, which can show the treatment thoughts of tonifying within clearing, reconciling yin and yang, and treating both symptoms and root causes.