摘要
目的探讨通痹胶囊联合中医情志干预对强直性脊柱炎(AS)患者的临床症状、炎性因子、血栓因子及不良情绪的影响。方法采用随机数字表法将我院收治的118例AS患者分为对照组和观察组,各59例。对照组给予柳氮磺胺吡啶(SASP)片治疗,观察组在对照组的基础上给予通痹胶囊治疗,两组均连续服用3个月,治疗期间两组患者均给予中医情志护理措施。治疗结束后观察两组患者治疗效果及临床症状缓解情况,检测并比较两组患者血清炎性因子和血栓因子水平变化,评估患者焦虑抑郁情绪的改善情况。结果治疗后观察组总有效率为88.14%,高于对照组的69.49%(P<0.05),治疗后两组患者晨僵时间、指地距和枕墙距较治疗前缩短,Dougados指数、BASFI较治疗前降低(P<0.05),且观察组上述指标均短于或低于对照组(P<0.05)。治疗后两组患者血清中IL-4、IL-17、CRP、TNF-α及观察组血清中TXB2、GMP140水平均较治疗前降低(P<0.05),且观察组低于对照组(P<0.05)。治疗后两组患者HAMA及HAMD评分均较治疗前降低(P<0.05),且观察组低于对照组(P<0.05)。结论通痹胶囊联合中医情志干预可改善AS患者的临床症状,缓解其不良情绪,治疗效果确切。
Objective To investigate the influence of Tongbi capsule combined with traditional Chinese medical(TCM) emotional intervention on clinical symptoms,inflammatory factors, thrombotic factors and unhealthy emotions in patients with ankylosing spondylitis(AS). Methods 118 cases of AS in our hospital were randomly divided into control group and observation group by using random digital table method, with 59 cases in each group. The control group was treated with sulfasalazine(SASP) tablets,and the observation group was treated with Tongbi capsule on the basis of the control group. The two groups were orally taken for 3 months continuously. During the treatment, the two groups were given the TCM emotional intervention. After treatment, the treatment effect and clinical symptom remission of the two groups were observed, and the levels of serum inflammatory and thrombotic factors were detected and compared,and the improvement of anxiety and depression in the patients were evaluated. Results After treatment the total effective rate of the observation group was 88.14%,which was significantly higher than that of the control group 69.49%(P<0.05). The morning stiffness, ground distance and occipital wall distance of the two groups after treatment were significantly shorter than those before treatment, and the Dougados index and BASFI significantly decreased(P<0.05),and the above indexes of the observation group were significantly shorter or lower than those of the control group(P<0.05). After the treatment, the levels of serum IL-4,IL-17,CRP,TNF-α in the two groups and the levels of serum TXB2 and GMP140 in the observation group were significantly lower than those before treatment (P<0.05),and the observation group was lower than the control group(P<0.05). After treatment, the scores of HAMA and HAMD in two groups were lower than those before treatment(P<0.05),and the observation group was lower than the control group(P<0.05). Conclusion The combination of Tongbi capsule and TCM emotional intervention can improve the clinical symptoms of AS patients,reduce the level of serum inflammatory factors and thrombus factors, and alleviate their unhealthy emotions, and the therapeutic effect is confirmed.
作者
杨丹
杨巧丽
王亚丽
YANG Dan;YANG Qiaoli;WANG Yali(Department of Traditional Chinese Medicine,Department of Rheumatology,Department of Acupuncture and Moxibustion,Baoji traditional Chinese Medicine Hospital of Shanxi Province,Baoji 721000,China)
出处
《宁夏医科大学学报》
2019年第1期97-101,共5页
Journal of Ningxia Medical University
基金
陕西省医学科学计划研究重点项目(LCMS008)
关键词
强直性脊柱炎
通痹胶囊
中医情志干预
炎性因子
情绪
ankylosing spondylitis
Tongbi capsule
TCM emotion intervention
inflammatory factors
emotion