联合检测类风湿因子、抗CCP抗体、免疫球蛋白对辅助诊断类风湿性关节炎的价值探讨

The Value of Combined Detection of Rheumatoid Factor, Anti-CCP Antibody and Immunoglobulin in the Diagnosis of Rheumatoid Arthritis

目的探讨联合检测类风湿因子、抗CCP抗体、免疫球蛋白对辅助诊断类风湿性关节炎的价值,为临床诊断提供可靠的参考依据。方法回顾分析2017年5月—2018年5月该院收治的52例类风湿性关节炎患者的临床资料,将其作为观察组,另选同期52例非类风湿性关节炎自身免疫性疾病患者的临床资料,将其作为对照组。结果观察组患者的类风湿因子、抗CCP抗体、免疫球蛋白阳性率(76.92%、50.00%、88.46%)要显著高于对照组(19.23%、9.62%、28.85%),组间差异有统计学意义(χ2=34.667,P=0.000;χ2=20.267,P=0.000;χ2=38.103,P=0.000);类风湿因子+抗CCP抗体+免疫球蛋白联合检测与类风湿因子+抗CCP抗体联合检测在观察组中的阳性检出率(96.15%、76.92%)均显著高于对照组(42.31%、32.69%),组间差异有统计学意义(χ2=35.389,P=0.000,χ2=20.536,P=0.000);类风湿因子+抗CCP抗体+免疫球蛋白联合检测的总阳性率(54.81%)高于类风湿因子+抗CCP抗体检测(69.23%),组间差异有统计学意义(χ2=4.592,P=0.032)。结论类风湿因子、抗CCP抗体、免疫球蛋白联合检测是提高类风湿性关节炎检出率的重要辅助方法,值得广泛推广。

Objective To investigate the value of combined detection of rheumatoid factor,anti-CCP antibody and immunoglobulin in the diagnosis of rheumatoid arthritis,and provide a reliable reference for clinical diagnosis.Methods The clinical data of 52 patients with rheumatoid arthritis admitted to the hospital from May 2017 to May 2018 were retrospectively analyzed.The clinical data of 52 patients with rheumatoid arthritis and autoimmune diseases were selected as the observation group.Another 52 cases of clinical data of nonautoimmune disease as a control group.Results The positive rate of rheumatoid factor,anti-CCP antibody and immunoglobulin (76.92%,50.00%,88.46%) in the observation group was significantly higher than that in the control group (19.23%,9.62%,28.85%),and the difference between the groups was significant (χ^2=34.667,P=0.000;χ^2=20.267,P=0.000;χ^2=38.103,P=0.000);combined detection of rheumatoid factor+anti-CCP antibody+immunoglobulin and rheumatoid factor+anti-CCP antibody The positive detection rate in the group (96.15%,76.92%) was significantly higher than that in the control group (42.31%,32.69%),and the difference between the groups was significant(χ^2=35.389,P=0.000,χ^2=20.536,P=0.000);The total positive rate of rheumatoid factor + anti-CCP antibody + immunoglobulin combined detection (54.81%) was higher than that of rheumatoid factor + anti-CCP antibody (69.23%),and the difference between groups was significant (χ^2=4.592,P=0.032).Conclusion The combined detection of rheumatoid factor,anti-CCP antibody and immunoglobulin is an important auxiliary method to improve the detection rate of rheumatoid arthritis,which is worthy of widespread promotion.