探讨急性心肌梗死检测B型钠尿肽及血浆同型半胱氨酸水平临床意义

Clinical significance of detecting B type natriuretic peptide and plasma homocysteine level in patients with acute myocardial infarction

目的:探讨B型钠尿肽(BNP)及血浆同型半胱氨酸水平(Hcy)在急性心肌梗死检测中的临床价值。方法:收治急性心肌梗死患者80例作观察组,另选取同时期健康体检者80名作对照组。记录观察组患者治疗前、后的BNP及Hcy水平;另对发生心血管事件的患者29例与未发生心血管事件患者51例的血浆BNP、Hcy水平进行比较。结果:观察组患者的血浆BNP、Hcy水平均高于对照组;观察组患者药物溶栓或经皮冠状动脉介入治疗后血浆BNP、Hcy水平均低于治疗前;观察组中发生心血管事件患者的血浆BNP、Hcy水平均明显高于未发生心血管事件的患者,各项数据组间比较差异均有统计学意义(P<0.05)。结论:血浆BNP与Hcy水平与急性心肌梗死存在紧密的联系,具有较好的临床检测价值。

Objective:To investigate the clinical value of B type natriuretic peptide(BNP)and plasma homocysteine(Hcy)in the detection of acute myocardial infarction.Methods:80 patients with acute myocardial infarction were selected as the observation group,and 80 healthy persons in the same period were selected as the control group.The levels of BNP and Hcy in the observation group before and after treatment were recorded.The plasma levels of BNP and Hcy were compared between 29 patients with cardiovascular events and 51 patients without cardiovascular events.Results:The plasma BNP and Hcy levels in the observation group were higher than those in the control group.The plasma BNP and Hcy levels of the patients in the observation group were lower than those before the treatment after the thrombolytic therapy or percutaneous coronary intervention.The plasma levels of BNP and Hcy in patients with cardiovascular events in the observation group were significantly higher than those in the patients without cardiovascular events,and the differences between the groups were all statistically significant(P<0.05).Conclusion:There is a close relationship between plasma BNP and Hcy levels and acute myocardial infarction,which has good clinical value.