葡萄膜黑色素瘤相关炎症浸润细胞及免疫治疗

Inflammatory infiltrating cells related to uveal melanoma and its immunotherapy

巨噬细胞、树突状细胞、自然杀伤细胞、淋巴细胞等免疫细胞,以及相关的白细胞介素-10、转化生长因子-β、干扰素-γ等细胞因子,在葡萄膜黑色素瘤中有着重要的作用机制。肿瘤细胞、免疫细胞和细胞因子之间独特的相互作用表明,免疫治疗可能是治疗葡萄膜黑色素瘤的有效方法。分析这三者之间动态关系的研究将不仅有助于理解肿瘤生长和免疫逃避的病理生理机制,而且有助于研究新的治疗方法。本文主要简述了葡萄膜黑色素瘤相关的免疫细胞、细胞因子对肿瘤细胞的作用,并回顾了常见的免疫治疗进展。

Immune cells,such as macrophages,dendritic cells,natural killer cell,and lymphocytes,as well as related cytokines such as IL-10,TGF-β,and IFN-γ,have an important mechanism in uveal melanoma.The unique interaction between tumor cells,immune cells,and cytokines suggests that immunotherapy may be an effective treatment for uveal melanoma.The analysis of their dynamic relationship will not only help to understand the pathophysiology of tumor growth and immune evasion,but also help to design new treatments.This article briefly describes the effects of uveal melanoma-associated immune cells and cytokines on tumor cells,and gives a review on the progress of common immunotherapy.