嗜黏蛋白阿克曼菌与肥胖的关系

Relationship between Akkermansia muciniphila and obesity

嗜黏蛋白阿克曼菌(A. muciniphila)是一种人类肠道的正常菌群,肥胖患者肠道菌群中的A. muciniphila丰度明显降低。许多证据表明A. muciniphila与肥胖、糖尿病、心血管疾病和低度炎症呈负相关。A. muciniphila不仅可以保护肠道上皮细胞及黏液层的完整性发挥代谢保护作用,在炎症反应过程中A. muciniphila也能通过调节性T细胞、内源性大麻素系统以及非经典Toll样受体发挥抗炎作用。本文就A. muciniphila与肥胖的相关性及分子机制、临床应用等作一综述。

Akkermansia muciniphila(A.muciniphila)is a normal flora of human gastrointestinal tract.The A.muciniphila abundance of intestinal flora in obese patients is significantly decreased.Many evidences suggest that A.muciniphila is negatively related to obesity,diabetes,cardiovascular diseases and low-grade inflammation.A.muciniphila not only plays a metabolic protective role by protecting the integrity of intestinal epithelial cells and mucus layer,but also plays an anti-inflammatory role by regulatory T cells,endogenous cannabinoid system and non-classical Toll-like receptor in the process of inflammatory reaction.This article reviews the relationship between A.muciniphila and obesity,and the molecular mechanism and application of A.muciniphila in obesity.