血管生成素-2、血管内皮生长因子、糖类抗原199及癌胚抗原对结肠癌诊断和复发转移的预测价值

Relationship between angiopoietin-2,vascular endothelial growth factor,carbohydrate antigen 199 and carcinoembryonic antigen in the diagnosis and postoperative recurrence and metastasis in colon cancer

目的探讨结肠癌患者血清中血管生成素-2(Ang-2)、血管内皮生长因子(VEGF)、糖类抗原199、癌胚抗原(CEA)对结肠癌患者的诊断及术后复发转移的预测作用。方法收集结肠癌患者100例,结肠良性病变100例,健康体检者100例;检测患者血清中Ang-2、VEGF、CA19-9、CEA的水平,并探讨其对结肠癌诊断及术后复发转移的评估价值。结果结肠癌组血清Ang-2、VEGF、CA19-9、CEA水平较结肠良性病变组和健康对照组均升高(P <0.05);联合检测Ang-2、VEGF、CA19-9、CEA水平较各项指标单独检测对结肠癌的诊断敏感性、特异性均升高;术前Ang-2、VEGF、CA19-9、CEA阳性患者术后早期复发转移率分别高于各自阴性患者,生存分析显示不同表达状态其远处转移出现时间差异有统计学意义(P <0.05)。结论检测血清中Ang-2、VEGF、CA19-9、CEA的水平对诊断结肠癌具有临床意义,联合检测可提高诊断效能;术前血清中Ang-2、VEGF、CA19-9、CEA的水平与结肠癌术后复发转移发生相关,联合检测有助于评估肿瘤转移情况。

Objective To investigate the diagnosis of colon cancer patients and the prediction of postoperative recurrence and metastasis in patients with colon cancer by serum angiopoietin-2(Ang-2),vascular endothelial growth factor(VEGF),carbohydrate antigen 199 and carcinoembryonic antigen CEA. Methods 100 patients with colon cancer,100 patients with benign colonic lesions and 100 healthy subjects were examined. The levels of Ang-2,VEGF,CA19-9 and CEA in serum were detected,and the diagnosis and postoperative recurrence and metastasis of colon cancer were investigated. Results The levels of serum Ang-2,VEGF,CA19-9 and CEA in colon cancer group were higher than those in benign lesions and healthy controls(P < 0.05). The levels of Ang-2,VEGF, CA19-9 and CEA were detected. The sensitivity and specificity of each index were significantly higher in the diagnosis of colon cancer. The preoperative recurrence and metastasis rates of patients with positive Ang-2,VEGF, CA19-9 and CEA were higher than those of the negative patients respectively. Survival analysis showed a statistically significant difference in the time of distant metastasis between different expression states(P < 0.05). Conclusion The detection of serum levels of Ang-2,VEGF,CA19-9 and CEA has clinical significance for the diagnosis of colon cancer. Combined detection can improve the diagnostic efficiency;the levels of Ang-2,VEGF,CA19-9 and CEA in serum before surgery colon cancer is associated with recurrence and metastasis,and combined testing can help to assess tumor metastasis.