补佳乐联合地屈孕酮预防宫腔粘连分离改松解术后粘连复发的临床效果评价

Clinical Effect of Bujiale Combined with Diprogesterone to Prevent Recurrent Adhesion after Separation and Lysis of Intrauterine Adhesions

目的:分析补佳乐联合地屈孕酮预防宫腔粘连分离改松解术后粘连复发的临床效果。方法:2015年4月～2018年3月,于某院收治的中度宫腔改宫腔粘连患者中选取80例,以治疗方式为依据分为两组,均采用宫腔粘连分离改松解术治疗,术后给予对照组患者口服补佳乐治疗,给予观察组患者联合补佳乐与地屈孕酮治疗,对比两组临床治疗效果。结果:观察组患者术后妊娠率、术后月经恢复率高于对照组,宫腔再次粘连率低于对照组,差异存在统计学意义,P<0.05;观察组头痛、乳房胀痛、胃肠道反应患者均为1例,对照组分别有1例、2例、1例,两组不良反应发生情况对比,差异不存在统计学意义,P>0.05。结论:补佳乐联合地屈孕酮预防宫腔粘连分离改松解术后粘连复发的临床效果显著,安全性高,存在有良好的临床推广价值。

Objective:To analyze the clinical effect of Bujiale combined with diprogesterone to prevent recurrent adhesion after separation and lysis of intrauterine adhesions.Methods:80 cases with moderate uterine cavity in the change caused by intrauterine adhesions in a hospital from April 2015 to March 2018 were divided into two groups on the basis of treatment,both groups were treated with separation and lysis of intrauterine adhesions,postoperative control group was given oral bujiale,and postoperative observation group was given Bujiale combined with diprogesterone,compared clinical therapeutic effect of two groups.Results:The postoperative pregnancy rate and postoperative menstrual recovery rate of the observation group were higher than the control group,and the rate of uterine readhesion was lower than that of the control group,the difference was statistically significant,P<0.05;In the observation group,there were 1 case of headache,1 case of breast flatulence and 1 case of gastrointestinal reaction,in the control group,there were 1 case,2 cases,1 case.There was no statistically significant difference between the two groups in the occurrence of adverse reactions,P>0.05.Conclusion:The clinical efficacy and safety of Bujiale combined with diprogesterone to prevent recurrent adhesion after separation and lysis of intrauterine adhesions is significant,and it has good clinical value.