丁苯酞联合多奈哌齐治疗血管性认知障碍的效果观察

Effect of butylphthalide combined with Donepezil on Vascular cognitive impairment

目的探讨丁苯酞胶囊联合多奈哌齐片治疗血管性认知功能障碍的临床效果。方法选取2015年3月至2017年10月在我院就诊的血管性认知障碍患者78例,并按照随机数字表法分为对照组和治疗组,各39例。对照组给予多奈哌齐片5mg,1次/日,连续治疗12周,治疗组在多奈哌齐片治疗基础上加用丁苯酞胶囊0. 2,2次/日,连续治疗12周。使用简易精神状态评定(MMSE)和蒙特利尔认知评估(MoCA)对两组患者治疗前以及治疗12周后的认知功能水平进行评分。结果两组在治疗之后MMSE和MoCA评分均有升高,但治疗组明显高于对照组,差异有统计学意义(P <0. 05);治疗过程中,两组的不良反应均很少,差异无统计学意义(P> 0. 05)。结论丁苯酞胶囊联合多奈哌齐片在血管性认知障碍的治疗中对于改善患者的智能水平、认知能力,延缓患者的病情发展有良好的作用。

Objective To explore the clinical effect of butylphthalide capsule combined with donepezil tablet in the treatment of vascular cognitive dysfunction.Methods 78 patients with vascular cognitive disorder admitted to our hospital from March 2015 to October 2017 were selected,and 39 patients were divided into control group and treatment group according to the random number table method.The control group was continuously treated with doneperazide tablets for 5mg qn for 12 weeks,and the treatment group was continuously treated with butylphthalide capsules for 12 weeks on the basis of this treatment.Cognitive function levels before and 12 weeks after treatment in two groups were assessed using simple mental state assessment(MMSE)and Montreal cognitive assessment(MoCA).Results After treatment,MMSE and MoCA scores of two groups both increased,but the treatment group was significantly higher than the control group,with statistically significant difference(P<0.05).During the treatment,the adverse reactions in both groups were small and the difference was not statistically significant(P>0.05).Conclusion Butylphthalide capsule combined with donepezil tablet has a good effect on improving the intelligence level and cognitive ability of patients and delaying the development of patients with vascular cognitive disorder.