口服美沙拉嗪联合康复新液保留灌肠治疗溃疡性结肠炎的疗效观察

Observation on efficacy of Mesalazine in combination with Kangfuxin solution enema in treatment of ulcerative colitis and effects on inflammatory factors and coagulation indexes

目的研究口服美沙拉嗪联合康复新液保留灌肠对溃疡性结肠炎患者炎性因子及凝血指标的影响,分析其临床疗效。方法选取2016年1月至2018年1月期间我院收治的溃疡性结肠炎患者80例作为临床研究对象,采用随机数字表法将所有患者随机分为对照组和观察组,两组各40例。对照组患者给予口服美沙拉嗪1. 0g/次治疗,每日3次;观察组在此基础上加用100ml康复新液保留灌肠治疗,每日1次。以1个月为1个疗程,比较两组患者治疗前及治疗2个疗程后血清炎症因子水平、机体凝血指标的差异,复查肠镜比较两组患者临床疗效。结果与治疗前相比,两组患者行不同干预治疗后血清C-反应蛋白(CRP)、肿瘤坏死因子-ɑ(TNF-ɑ)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)水平均明显降低(P <0. 05),其部分凝血酶原时间(APTT)、纤维蛋白原(FIB)、血小板(PLT)、平均血小板体积(MPV)水平也明显改善(P <0. 05)。与对照组相比,治疗后观察组患者血清CRP,TNF-ɑ,IL-6,IL-8等炎症因子水平明显偏低(P <0. 05),且观察组FIB和PLT水平明显低于对照组(P <0. 05),APTT和MPV水平则明显优于对照组水平(P <0. 05),组间差异具有统计学意义。复查肠镜结果显示,观察组患者总有效率明显高于对照组患者(P <0. 05),差异具有统计学意义。结论口服美沙拉嗪联合康复新液保留灌肠可有效抑制溃疡性结肠炎患者血清炎症因子分泌,降低血液高凝状态,缓解临床症状,促进康复。

Objective To probe into the efficacy of mesalazine in combination with Kangfuxin solution enema in treatment of ulcerative colit and Effects on Inflammatory Factors and Coagulation Indexes.Methods 80 patients with ulcerative colitis admitted into our hospital from Jan.2016 to Jan.2018,and randomly divided into observation group(n=40)and the control group(n=40)equally.In the control group,1 g mesalazine for oral administration was provided in each time,three times per day,while the observation group was treated in combination with 100 ml Kangfuxin solution enema once per day on the basis of the control group,and one course of treatment lasted one month.After two-month treatment,colonoscopy was used while the curative effcacy,levels of in?ammatory factors and coagulation parameters were compared.Results After treatment,CRP,TNF-ɑ,IL-6,TL-8 level in the two groups were significantly reduced when compared with before treatment(P<0.05),and the CRP、TNF-ɑ、IL-6、TL-8 level of observation group were significantly lower than those of control group,with statistically significant difference(P<0.05).APTT,FIB,PLT,MPV of two groups were significantly improved than that before treatment(P<0.05).In comparison with the control group after treatment,the observation group had statistically lower levels of FIB and PLT(P<0.05),and higher level of APTT and MPV(P<0.05).Observed under colonoscopy,the total effective rate in the observation group was higher than the control group,and there was significant difference of the total effective rate between the two groups(P<0.05).Conclusion Combined treatment of oral administration of mesalazine and Kangfuxin solution enema can alleviate inflammatory reaction and improve the coagulation parameters indexes of patients with ulcerative colitis,improve the clinical curative effect,it has certain value in clinical application and research.