心理行为干预联合盐酸洛美利嗪治疗慢性偏头痛患者的疗效观察

Effect of psychological behavior intervention combined with lomezine hydrochloride on anxiety symptoms and clinical efficacy of chronic migraine patients

目的探讨心理行为干预联合盐酸洛美利嗪对偏头痛患者焦虑症状及临床疗效影响及安全性。方法将入选的64例偏头痛患者随机分为对照组及试验组,对照组32例口服盐酸洛美利嗪5mg/次,2次/日;试验组32例在口服盐酸洛美利嗪基础上进行有计划有针对性的心理行为干预,两组患者于治疗前、干预后4周、干预后12周末用焦虑自评量表(SAS)进行问卷调查,临床疗效以头痛发作频率为主要评定指标,发作频率、持续时间、程度、伴随的症状及头痛综合评分,并记录不良反应。结果 4周及12周试验组SAS评分明显低于对照组,12周差别最明显,具有显著性差异(P <0. 05);头痛发作频率、持续时间、程度、伴随症状及头痛综合评分较对照组显著降低(P <0. 01);两组治疗期间均无严重不良反应。结论心理行为干预联合盐酸洛美利嗪更有效地缓解患者焦虑症状,有效缓解头痛症状,减少发作,从而提高临床疗效。

Objective To explore the effect and safety of psychological behavior intervention combined with lomeizine hydrochloride on anxiety symptoms and clinical efficacy of migraine patients.Methods 64 patients with migraine were randomly divided into control group and experimental group,and 32 cases in control group(5mg/times,2 times/day of lomezine hydrochloride).The experimental group was given a planned and targeted psychological and behavioral intervention based on lomezizine hydrochloride.The two groups were investigated by self rating Anxiety Scale(SAS)before and after 4 weeks,12 weeks after the intervention,The main outcome measures were headache frequency,duration of onset,duration,degree of symptoms and headache,and adverse reactions.Results 4 and 12 weeks in the experimental group SAS score was significantly lower than the control group,the most obvious at 12 weeks(P<0.05)has significant difference;the headache frequency,duration,degree of associated symptoms and headache scores were significantly lower than the control group(P<0.01);the two groups during treatment there were no serious adverse reaction.Conclusion Psychological behavioral intervention combined with lomeprozin hydrochloride is more effective in relieving anxiety symptoms,relieving headache symptoms and reducing seizures,so as to improve clinical efficacy.