动脉粥样硬化、急性冠脉综合征患者血清HDL2b水平变化及临床意义

Serum HDL2b level changes and clinical significance in patients with atherosclerosis and acute coronary syndrome

目的研究动脉粥样硬化、急性冠脉综合征患者血清高密度脂蛋白2b(HDL2b)水平变化及临床意义。方法选取2016年2月～2017年12月中国人民武装警察部队浙江省总队医院(以下简称"我院")收治的动脉粥样硬化患者81例记为A组,另取同期我院收治的急性冠脉综合征患者175例记为B组,再取同期于我院进行体检的健康人员100名记为对照组。分别比较三组血清HDL2b水平以及各项血脂指标水平,并分析其相关性;比较冠状动脉病变不同程度的急性冠脉综合征患者的血清HDL2b水平。结果 A、B组血清HDL2b水平均低于对照组,B组血清HDL2b水平低于A组,差异均有统计学意义(P <0.05)。A、B组HDL-C水平均低于对照组,B组HDL-C水平低于A组,差异均有统计学意义(P <0.05)。Pearson相关性分析结果提示,B组血清HDL2b与HDL-C呈正相关(P <0.05)。单支病变组、双支病变组、多支病变组患者血清HDL2b水平呈降低趋势,且单因素方差分析提示,各组间差异均有统计学意义(P <0.05)。结论动脉粥样硬化、急性冠脉综合征患者血清HDL2b水平均呈低表达,临床工作中可通过检测血清HDL2b水平,从而明确患者代谢紊乱和疾病的关系,可为临床治疗方案的制订提供指导作用。

Objective To study the changes and clinical significance of serum high density lipoprotein 2b(HDL2b)in patients with atherosclerosis and acute coronary syndromes.Methods A total of 81 cases with atherosclerosis admitted to Zhejiang Provincial General Hospital of Chinese People′s Armed Police Force(“our hospital”for short)from February 2016 to December 2017 were selected as group A,another 175 cases with acute coronary syndrome admitted to our hospital in the same period were selected as group B,and then 100 healthy individuals that performed physical examination in our hospital in the same period were taken as control group.Serum HDL2b level and serum lipid level were compared among the three groups,and their correlation was analyzed.Serum HDL2b levels were compared in patients with acute coronary syndrome of different degrees coronary artery disease.Results The serum level of HDL2b in group A and B were lower than that in the control group,and the serum level of HDL2b in group B was lower than that in group A,the differences were statistically significant(P<0.05).High density lipoprotein cholesterol(HDL-C)level in group A and B were lower than that in the control group,and HDL-C level in group B was lower than that in group A,and the differences were statistically significant(P<0.05).According to the Pearson correlation analysis results,there was a positive correlation between serum HDL2b and HDL-C in group B(P<0.05).There was a decreasing tendency of HDL2b level in the single vessel lesion group,double vessels lesion group,multiple vessels lesion group orderly.Single factor analysis of variance could prompt that the differences among the three groups were statistically significant(P<0.05).Conclusion Serum HDL2b levels is low expressed in patients with atherosclerosis and acute coronary syndrome.In clinic,the relationship between metabolic disorder and disease can be determined by detecting serum HDL2b level,and it can provide guidance for clinical treatment therapy.