他汀类药物治疗年龄大于80岁老年血脂异常患者的效果

Effect of the statins to the elder patients over 80 years old with dyslipidemia

目的探讨他汀类药物在年龄>80岁的血脂异常老年人群中临床应用的获益情况及安全性,从而为老年人群临床应用他汀类药物提供依据。方法选取2014年8月～2017年5月在编的年龄>80岁且血脂异常的上海市黄浦区离休干部80例,采用随机数字表法分为对照组和研究组,各40例。对照组予血脂宣教、低脂饮食、适当运动;研究组在对照组治疗方案基础上,每晚口服40 mg普伐他汀。随访6个月血脂、肝肾功能、肌酶、炎症因子变化情况并进行分析。结果对照组治疗后总胆固醇和尿酸水平均明显低于治疗前,差异有统计学意义(P <0.05)。研究组治疗后总胆固醇、低密度脂蛋白胆固醇、肿瘤坏死因子、白介素-6水平均明显低于治疗前,差异有统计学意义(P <0.05)。治疗后,研究组总胆固醇水平低于对照组,差异有统计学意义(P <0.05)。结论普伐他汀应用于年龄>80岁的人群,可显著降脂、减少炎症因子等,对于肝肾功能、肌酶、心室功能等方面无明显副作用。

Objective To investigate the benefit and safety situation of statins delivered to the elder people over 80 years old with dyslipidemia in clinical practice,and consequently provide guideline for the statins therapy applied to the elder people.Methods A total of 80 cases of the registered retired officers over 80 years old from August 2014 to Mag 2017 in Huangpu District,Shanghai,with dyslipidemia were selected.According to the random number table method,all the cases were divided into control group and study group,with 40 cases in each group.The control group was given blood lipid knowledge education,low fat diet and proper physical practice;the study group was given 40 mg/d Pravastatin po qn on the basis of the therapy of the control group.The two groups were followed up for 6 months about blood lipid,hepatorenal function,myocardial enzyme and inflammatory factor and analysis was performed.Results After treatment,the total cholesterol and uric acid level of the control group significantly reduced compared with those before treatment,and the difference was significant(P<0.05).After treatment,the total cholesterol,low density lipoprotein-cholesterol,tumor necrosis factor and interleukins-6 levels significantly reduced compared with those before treatment,and the difference was significant(P<0.05).After treatment,the total cholesterol level of the study group was significantly lower than the control group,and the difference was significant(P<0.05).Conclusion Applying to elder people over 80 years old,Pravastatin can reduce blood lipid and inflammatory factor,meanwhile it has no obvious side effects on hepatorenal function,creatase and ventricular function.