P37、P16、PAX-2在子宫内膜增生症中的表达及其意义

Expression and significance of P37, P16 and PAX-2 in endometrial hyperplasia

目的分析P37、P16、PAX-2在子宫内膜增生症中的表达及其意义。方法收集2012年12月～2017年8月河北省秦皇岛市妇幼保健院接受病理活检,并经病理组织学活检确诊为子宫内膜增生患者的病理组织标本,其中单纯型及复杂型子宫内膜增生标本31个、不典型子宫内膜增生组织标本30个;另选取30个正常子宫内膜组织标本作为对照。采用免疫组化SP法检测不同组织标本中P37、P16及PAX-2蛋白阳性表达率。结果正常子宫内膜组织中未见P37蛋白阳性表达,不典型增生症组织中阳性表达率高于单纯型或复杂型增生症,差异有统计学意义(P <0.05);不典型增生组织中P16蛋白阳性表达<单纯型或复杂型增生<正常子宫内膜组织,差异有高度统计学意义(P <0.01);不典型增生组织中PAX-2蛋白阳性表达<单纯型或复杂型增生<正常子宫内膜组织,差异有高度统计学意义(P <0.01)。结论 P37、P16、PAX-2在不典型子宫内膜增生中均有一定异常表达,值得进一步深入探究。

Objective To analyze the expression and significance of P37,P16 and PAX-2 in endometrial hyperplasia.Methods From December 2012 to August 2017,in Qinhuangdao Maternal and Child Health Hospital,the pathological tissue specimens of patients with endometrial hyperplasia diagnosed by pathological biopsy were selected,including 31 specimens of simple and complicated endometrial hyperplasia and 30 specimens of atypical endometrial hyperplasia;30 normal endometrium specimens were selected as controls.The positive expression rates of P37,P16 and PAX-2 protein in different tissue specimens were detected by immunohistochemical SP method.Results There was no positive expression of P37 protein in normal endometrium tissues,the positive expression rate in atypical hyperplasia was higher than simple or complex hyperplasia,the difference was statistically significant(P<0.05).The positive expression of P16 protein showed atypical dysplasia tissue<simple or complex hyperplasia<normal endometrium tissue,the difference was statistically significant(P<0.01),while the positive expression of PAX-2 protein showed atypical dysplasia<simple or complex hyperplasia<normal endometrium tissue,the difference was statistically significant(P<0.01).Conclusion There exists abnormal expression of P37,P16 and PAX-2 in atypical endometrial hyperplasia,which is worthy of further study.