血清淀粉样蛋白A1(SAA1)在结直肠癌中的表达及其临床意义

Expression and Clinical Significance of Serum Amyloid A1 (SAA1) in Colorectal Cancer

目的研究血清淀粉样蛋白A1 (SAA1)在结直肠癌(CRC)中的表达情况及其临床意义。方法选取2012年7月至2015年10月就诊于锦州医科大学附属第一医院的195例结直肠癌患者,采用免疫组织化学法分析其CRC组织中的SAA1蛋白表达水平。我们采用Pearson卡方检验分析SAA1的表达情况与临床病理参数之间的相关性。应用单变量和多变量Cox回归分析评估SAA1在CRC患者中的预后价值。使用Kaplan-Meier分析进一步调查了195名CRC患者中SAA1表达与总体生存(OS)之间的关联。结果在195例结直肠癌患者中SAA1高表达有100例,Pearson卡方检验结果显示SAA1在CRC中的表达水平与淋巴结转移(P=0. 034)、远处转移(P=0. 041)及TNM分期(P=0. 033)显著相关;多变量Cox回归分析显示SAA1是CRC患者OS的独立预后危险因素(P=0. 005); Kaplan-Meier分析结果显示,高表达组患者的平均生存时间显著低于低表达组(P<0. 05)。结论 SAA1的过表达可能促进CRC的发生与发展而且是CRC患者预后不良的标记物。

Objective To study the expression and clinical significance of serum amyloid A1(SAA1)in colorectal cancer(CRC).Methods A total of 195 patients with colorectal cancer who were admitted to the First Affiliated Hospital of Jinzhou Medical University from July 2012 to October 2015 were enrolled.The expression level of SAA1 protein in CRC tissues was analyzed by immunohistochemistry.We used Pearson chi-square test to analyze the correlation between SAA1 expression and clinicopathological parameters.Univariate and multivariate Cox regression analyses were used to assess the prognostic value of SAA1 in patients with CRC.Kaplan-Meier analysis was used to further investigate the association between SAA1 expression and overall survival(OS)in 195 CRC patients.Results There were 100 cases of high expression of SAA1 in 195 colorectal cancer patients.Pearson chi-square test showed that the expression of SAA1 in CRC was significantly correlated with lymph node metastasis(P=0.034),distant metastasis(P=0.041)and TNM stage(P=0.033),multivariate Cox regression analysis showed that SAA1 was an independent prognostic risk factor for OS in CRC patients(P=0.005),Kaplan-Meier analysis showed that the average survival time was significantly shorter in the high-expression group than that in the low-expression group(P<0.05).Conclusion Over-expression of SAA1 may promote the occurrence and development of CRC and is a marker of poor prognosis in CRC patients.