奥美拉唑与血凝酶联合治疗老年慢阻肺急性加重期伴消化道出血的临床研究

目的:探讨奥美拉唑与血凝酶联合治疗老年慢阻肺急性加重期伴消化道出血的临床效果。方法:选择我院2017年5月至2018年5月收治的老年慢阻肺急性加重期伴消化道出血患者94例为研究对象,随机分为对照组和联合组,两组均采用止咳、平喘等常规治疗,对照组在常规治疗基础上采用西咪替丁注射液治疗,联合组在常规治疗基础上采用奥美拉唑和血凝酶治疗,对比两组临床疗效、临床症状积分、止血时间及不良反应发生情况。结果:联合组临床总有效率91.49%,对照组68.09%,组间比较差异显著(P<0.05);联合组喘息、咳嗽、咳痰、肺部呼吸音症状积分明显低于对照组,止血时间明显短于对照组(P<0.05);联合组不良反应发生率与对照组差异较小(P>0.05)。结论:奥美拉唑与血凝酶联合治疗老年慢阻肺急性加重期伴消化道出血效果显著,其可显著改善患者咳嗽、喘息等临床症状,并缩短止血时间,且具有较高安全性,值得在临床上广泛应用。

Objective:To explore the clinical effect of Omeprazole combined with hemagglutinase in the treatment of senile chronic obstructive pulmonary disease complicated by acute exacerbation of gastrointestinal hemorrhage.Methods:A total of 94 patients with acute exacerbation of chronic obstructive pulmonary disease complicated by gastrointestinal hemorrhage admitted to the Hospital from May 2017 to May 2018 were enrolled in this study.They were randomly divided into a control group and a combined treatment group.Both groups were treated with routine treatment for cough and phlegm.The control group was treated additionally with Cimetidine Injection,and the combined treatment group was treated with Omeprazole and hemagglutinase additionally.The clinical efficacy,clinical symptom score,and time to achieve hemostasis,and adverse reactions were compared between the two groups.Results:The total effective rate of treatment was 91.49%in the combined treatment group and 68.09%in the control group,with significant difference between the two groups(P<0.05).The scores of wheezing,cough,expectoration,and lung breath sounds in the combined treatment group were significantly lower than those in the control group,significantly lower than those in the control group(P<0.05).The incidence of adverse reactions in the combined treatment group was less than that in the control group(P>0.05).Conclusion:For 94 patients with acute exacerbation of chronic obstructive pulmonary disease,Omeprazole combined with hemagglutinase is with significant curative effects and great safety,which can significantly improve the clinical symptoms such as cough and wheezing,shorten the time for achieve hemostasis;therefore,it is of significant value to be widely used in clinical practice.