高尿酸血症及痛风患者用药特点的横断面调查

A Cross Sectional Survey of Medication Features of Hyperuricemia and Gout Patients

目的了解高尿酸血症及痛风患者的用药现状,为合理用药提供参考。方法收集2018年1—6月中国中医科学院广安门医院南区门诊1 397例高尿酸血症及痛风患者的处方,统计其疾病名称、药品名称、用药种类等信息,对降尿酸药、抗炎镇痛药、常见合并症用药(降压药、调节血脂药、降糖药、抗血小板药)及中成药等应用情况进行分析。结果 89. 76%(1 192/1 328)的高尿酸血症及痛风患者应用降尿酸药,以单用苯溴马隆片(31. 70%,421/1 328)、碳酸氢钠片(27. 03%,359/1 328)及两者联用(15. 81%,210/1 328)多见; 46. 95%(154/328)的痛风患者应用抗炎镇痛药,以应用美洛昔康片(21. 95%,72/328)、洛索洛芬钠片(14. 94%,49/328)者居多; 40. 89%(543/1 328)的高尿酸血症及痛风患者应用降压药,以血管紧张素受体阻滞剂(37. 42%,497/1 328)、钙通道阻滞剂(23. 64%,314/1 328)居多; 30. 35%(403/1 328)的高尿酸血症及痛风患者应用调节血脂药,以他汀类药物(24. 47%,325/1 328)居多; 21. 91%(291/1 328)的高尿酸血症及痛风患者应用降糖药,以二甲双胍(13. 33%,177/1 328)、阿卡波糖(7. 08%,94/1 328)居多;抗血小板药物中,应用阿司匹林肠溶片者占16. 34%(217/1 328)、应用硫酸氢氯吡格雷片者占6. 17%(82/1 328); 31. 10%(413/1 328)的高尿酸血症及痛风患者应用中成药,以祛湿类(23. 12%,307/1 328)、化瘀类(15. 81%,210/1 328)、补益类(8. 66%,115/1 328)居多。结论门诊高尿酸血症及痛风患者用药基本合理,但在个别品种的选择上需进一步优化。

Objective To understand the medication status of hyperuricemia and gout patients,to provide reference for rational drug use. Methods The medical records of 1 397 outpatients with hyperuricemia and gout in South of Guang′anmen Hospital,China Academy of Chinese Medical Sciences during Jan. 1st and Jun. 30th of 2018 were collected.The disease names,drug names and types were recorded;medicines of uric-acid-lowering,anti-inflammatory,analgesic and drugs for the complications,such as hypertension,hyperlipemia,diabetes,antiplatelet drug and Chinese patent medicine were analyzed . Results 89.76%(1 192/1 328) of patients with hyperuricemia and gout were treated with uric-acid-lowering drugs,most patients used benzbromarone(31.70%,421/1 328),sodium bicarbonate tablets(27.03%,359/1 328) or both of them(15.81%,210/1 328).46.95%(154/328) of gout patients received anti-inflammatory and analgesic drugs,such as meroxicam (21.95%,72/328) and loxoprofen sodium tablets(14.94%,49/328).40.89%(543/1 328) of the patients were treated with antihypertensive drugs,and the majority was angiotensin receptor blocker(37.42%,497/1 328) and calcium channel blocker(23.64%,314/1 328).30.35%(403/1 328) of the patients were treated with lipid- regulating drugs,and the most commonly used drugs were statins(24.47%,325/1 328).21.91%(291/1 328) of the patients received antidiabetic drugs,and metformin(13.33%,177/1 328) and acarbose(7.08%,94/1 328) were the main drugs.As for the antiplatelet drugs,aspirin and clopidogrel accounted for 16.34%(217/1 328),6.17%(82/1 328),respectively.31.10%(413/1 328) of the patients received Chinese patent medicine,which were mainly clearing dampness drugs(23.12%,307/1 328),stasis-dissolving drugs(15.81%,210/1 328) and restoratives drugs(8.66%,115/1 328). Conclusion The drug treatment for patients with hyperuricemia and gout in the outpatient department is basically rational,but the selection of some medicines needs to be further optimized.