姜黄素对肾缺血再灌注损伤的保护作用机制的研究进展

Research progress on the protective mechanism of curcumin on renal ischemia reperfusion injury

姜黄素是一种从姜黄中提取的黄色酸性酚类物质,广泛应用于食品工业中。肾脏作为内分泌器官,同时也是高灌注器官,对缺血和再灌注尤其敏感。当肾脏出现缺血再灌注时,在缺血再灌注的后期会产生大量的活性氧族,使肾脏处于高度氧化应激状态,并引发一系列有害的细胞反应,导致炎症、细胞凋亡和急性肾衰竭,甚至引起其他器官的损害。姜黄素可以通过上调APPL1的表达、抑制Akt磷酸化途径、抑制活化的INOS/NO/CGMP/PKG信号通路、减轻氧化应激反应、抑制炎症细胞浸润,上调HO-1、抑制NF-κB活性、减少血管活性物质的产生等减少肾缺血再灌注所致的肾损伤。因此姜黄素可作为治疗肾缺血再灌注的一种新的治疗方法。

Curcumin is a yellow acid phenolic substance extracted from Rhizoma Curcumae longae and widely used in the food industry. The kidney acts as an endocrine organ and is also a high perfusion organ, particularly sensitive to ischemia and reperfusion. When the kidney develops ischemia-reperfusion, a large amount of reactive oxygen species is produced in the later stage of ischemia-reperfusion, which causes the kidney to be in a state of high oxidative stress and triggers a series of harmful cellular reactions, leading to inflammation, apoptosis and acute kidney failure, and even can cause damage to other organs. Curcumin can up-regulate the expression of APPL1, inhibit the Akt phosphorylation pathway, inhibit the activated INOS/NO/CGMP/PKG signaling pathway, alleviate oxidative stress, inhibit inflammatory cell infiltration, up-regulate HO-1, and inhibit NF-κB activity, reduce the incidence of vasoactive substances and reduce renal damage caused by renal ischemia and reperfusion. Therefore, curcumin can be used as a new treatment method for renal ischemia-reperfusion.