金黄膏走罐辅助凉血平银饮治疗银屑病的临床效果

Clinical effect of Liangxue Pingyin Decoction assisted by Jinhuang Ointment moving cupping in the treatment of psoriasis

目的探讨金黄膏走罐辅助凉血平银饮治疗银屑病的临床效果。方法选取长沙市第一医院2016年2月～2018年1月收治的110例寻常型银屑病患者,采用随机数字表法将其分为联合组和对照组,各55例。两组患者均给予西医基础疗法和凉血平银饮治疗,联合组同时采用金黄膏走罐辅助治疗,疗程2个月。比较两组患者治疗前后的炎症指标、免疫学指标、银屑病面积、病情严重程度(PASI)评分及皮肤病生活质量指数(DLQI)等。结果治疗前,两组患者白细胞介素-17(IL-17)、白细胞介素-23(IL-23)、免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、血清C反应蛋白(CRP)、血沉(ESR)水平和PASI评分、DLQI评分比较,差异无统计学意义(P>0.05);治疗后,两组患者的IgG、CRP、ESR、IL-17、IL-23水平和PASI、DLQI评分均较治疗前显著降低(P <0.05),IgM较治疗前显著升高(P <0.05)。治疗后,联合组患者的IL-17、IL-23、IgG、CRP、ESR水平和PASI、DLQI评分均低于对照组(P <0.05),IgM水平高于对照组(P <0.05)。结论金黄膏走罐辅助中医方剂凉血平银饮治疗银屑病能有效改善患者病情,降低血清IL-17、IL-23、CRP、ESR水平,调节患者免疫功能,提高患者生活质量。

Objective To explore the clinical effect of Liangxue Pingyin Decoction assisted by Jinhuang Ointment moving cupping in the treatment of psoriasis. Methods A total of 110 patients with psoriasis vulgaris admitted to the First Hospital of Changsha from February 2016 to January 2018 were selected. According to the random number table method, they were divided into combined group and control group, with 55 cases in each group. Both groups were treated with Western medicine basic therapy and Liangxue Pingyin Decoction, and the combined group was also treated with Jinhuang Ointment moving cupping as an auxiliary treatment, the course was 2 months. The inflammatory index, immunological index, psoriasis area disease severity (PASI) score and dermatology life quality index (DLQI) before and after treatment were compared between the two groups. Results There were no significant differences of interleukin-17 (IL-17), interleukin-23 (IL-23), immune globulin G (IgG), immune globulin A (IgA), immune globulin M (IgM), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) levels, and the scores of PASI, DLQI between the two groups before treatment (P > 0.05). After treatment, the levels of IgG, CRP, ESR, IL-17, IL-23 and the scores of PASI and DLQI of the two groups were significantly lower than those before treatment (P < 0.05), the levels of IgM were significantly higher than those before treatment (P < 0.05). After treatment, the levels of IL-17, IL-23, IgG, CRP, ESR and the scores of PASI and DLQI of the combined group were lower than those of the control group (P < 0.05), the level of IgM in the combined group was higher than that in the control group (P < 0.05). Conclusion Traditional Chinese medicine prescription Liangxue Pingyin Decoction assisted by Jinhuang Ointment moving cupping in the treatment of psoriasis can effectively improve the patients′ conditions, reduce the serum levels of IL-17, IL-23, CRP, ESR, regulate the immune function of patients, raise the quality of life of patients.