炎症因子在圆锥角膜发病机制中的研究进展

A review on inflammation cytokines in pathogenesis of keratoconus

圆锥角膜(keratoconus,KC)是一种渐进性角膜变薄性疾病,通过角膜膨隆,导致锥状外观,瘢痕形成以及视力下降。各种遗传因素、环境因素(眼摩擦,隐形眼镜磨损,紫外线照射)都与其病因相关。除了遗传和环境因素外,在此过程中炎性发病机制也越来越受到学者重视。本文涵盖了与之最相关和最近发表的关于炎症生物标志物,以进一步阐述圆锥角膜的发病机制,以期为圆锥角膜的治疗提供新思路。

Keratoconus(KC)is a progressive corneal thinning disease which can cause the conical appearance,scar growth and vision loss via corneal ectasia.Various factors were demonstrated to be related to its etiology,including the genetic factors and the environmental factors(i.e.the friction of eyelids and eyeball,the friction of contact lens and eyeball and the UV irradiation).In addition to the genetic and environmental factors,the inflammation cytokines has been reported as another key factor to the pathogenesis of keratoconus,thus received more attention recently.This paper then reviews the recent advances on the effect of inflammation cytokines on pathogenesis of keratoconus.The motivation of this work is to provide important guidance and thoughts for the treatment of keratoconus.