TRP离子通道在瘙痒中的作用及机制研究进展

Role and mechanism of TRP ion channels in pruritus

瘙痒是由多种原因引起的令人不快的皮肤感觉,虽然瘙痒不会威胁到生命,但长期慢性瘙痒会严重影响患者的生活质量。瞬时感受器电位离子通道(transient receptor potential ion channels, TRP)参与从感觉到皮肤平衡的生理过程。大量研究已经证实,许多瘙痒介质诱发的痒与TRP离子通道的激活有关。该文首先就瘙痒与疼痛的区别进行阐述,并就TRP离子通道在多种瘙痒介质诱发瘙痒中的作用及机制进行详细阐述,为瘙痒治疗提供新的思路。

Pruritus is an unpleasant noxious sensation induced by a variety of causes.Although pruritus does not cause death directly,long-term chronic pruritus severely reduces the quality of life of patients.TRP(transient receptor potential ion channels)participate in the physiological process from the sensation to skin balance.A large number of studies have confirmed that many itch media are involved in signal transduction related to TRP ion channels.We review the difference between itch and pain,and the role and mechanism of TRP in itch,so as to provide new research targets for treatment of pruritus.