诱导脂肪干细胞成软骨分化的研究进展

Research advance in chondrogenic differentiation of adipose-derived stem cells

由创伤或其他病因引起的关节软骨病变通常难以自愈,且目前临床上的治疗方法疗效欠佳。脂肪干细胞(adipose derived stem cells,ADSCs)是一种来自脂肪组织、具有多向分化潜能的干细胞,基于ADSCs成软骨分化能力的组织工程学疗法为关节软骨缺损的修复再生提供了新的思路。体外诱导ADSCs分化成软骨的方法主要是采用生长因子和支架材料模拟体内微环境,进而促进ADSCs向软骨细胞分化,其相关应用已取得初步成功。

Articular cartilage lesions due to injury or other pathology are often difficult to heal, and the outcomes of the clinical treatment widely used today are far from satisfaction. Adipose-derived stem cells (ADSCs) are multipotent stem cells from adipose tissue. Tissue engineering based on the ability of ADSCs to differentiate into chondrocytes provides a new idea for the repair and regeneration of articular cartilage defects. Th e method for inducing the diff erentiation of ADSCs into chondrocytes in vitro who have been quite well established, which mainly include the use of growth factors and scaffolds to mimic the in vivo microenvironment, thereby promoting the diff erentiation of ADSCs into chondrocytes.