玻璃体腔注射雷珠单抗注射液治疗眼底病的效果

Effect of intravitreal injection of ranibizumab injection on fundus diseases

目的探讨玻璃体腔注射雷珠单抗注射液治疗眼底病的效果。方法 90例眼底病患者,随机分为对照组和观察组,每组45例。对照组予以常规药物治疗,观察组予以常规药物联合玻璃体腔注射雷珠单抗注射液治疗。比较两组患者的效果。结果观察组患者的临床治疗总有效率为97.78%,显著高于对照组的71.11%,差异具有统计学意义(P<0.05)。治疗前,两组患者视网膜厚度、视力、眼压水平比较差异无统计学意义(P>0.05);治疗后,观察组患者视网膜厚度、视力、眼压水平均优于对照组,差异具有统计学意义(P<0.05)。观察组患者新生血管消失时间、视网膜水肿消失时间、视网膜出血消失时间、恢复正常视网膜厚度时间均优于对照组,差异具有统计学意义(P<0.05)。观察组患者的切口不愈合发生率为6.67%,与对照组的8.89%比较,差异无统计学意义(P>0.05)。两组切口不愈合患者经处理后均治愈。结论常规药物联合玻璃体腔注射雷珠单抗注射液治疗眼底病的疗效确切,可有效改善视网膜厚度、视力、眼压水平,促使症状消退,无明显不良反应,值得推广应用。

Objective To discuss the effect of intravitreal injection of ranibizumab injection on fundus diseases. Methods A total of 90 patients with fundus disease were randomly divided into control group and observation group, with 45 cases in each group. The control group was treated with conventional medicine, and the observation group was treated with conventional medicine combined with intravitreal injection of ranibizumab injection. The effect in two groups was compared. Results The observation group had significantly higher total effective rate of clinical treatment as 97.78% than 71.11% in the control group, and the difference was statistically significant (P<0.05). Before treatment, both groups had no statistically significant in retinal thickness, visual acuity and intraocular pressure (P>0.05). After treatment, the observation group had better retinal thickness, visual acuity and intraocular pressure than the control group, and their difference was statistically significant (P<0.05). The observation group had better disappearance time of neovascularization, retinal edema, retinal hemorrhage and normal retinal thickness recovery time than the control group, and their difference was statistically significant (P<0.05). The observation group had no statistically significant in incision nonunion rate as 6.67%, comparing with 8.89% in the control group (P>0.05). All patients with nonunion of incision in two groups were cured after treatment. Conclusion Combination of conventional medicine and intravitreal injection of ranibizumab injection shows affirmative efficacy in treating fundus disease, and it can effectively improve retinal thickness, visual acuity and intraocular pressure, and promote symptoms to subside without obvious adverse reactions. It is worth popularizing and applying.