乌司他丁治疗重症胰腺炎的效果观察

Observation on effect of ulinastatin in treatment of severe pancreatitis

目的探讨常规药物联合乌司他丁治疗重症胰腺炎的应用效果。方法回顾性分析2015年6月～2017年6月90例重症胰腺炎患者,根据随机数字表法分组。对照组给予单一常规药物治疗(34例),观察组则给予常规药物联合乌司他丁治疗(56例)。其中,根据乌司他丁剂量分为两组,A组给予乌司他丁10万单位(30例),B组给予40万单位(26例)。比较两组重症胰腺炎控制率,腹痛消失时间、淀粉酶达标时间、总住院时间,干预前后患者血淀粉酶、炎症指标,药物不良反应率。结果观察组重症胰腺炎控制率高于对照组,且B组治疗效果高于A组,P <0.05;观察组腹痛消失时间、淀粉酶达标时间、总住院时间短于对照组,P <0.05;干预前两组血淀粉酶、炎症指标相近,P> 0.05;干预后观察组血淀粉酶、炎症指标优于对照组,P <0.05。观察组药物不良反应率和对照组无明显差异,P> 0.05。结论常规药物联合乌司他丁治疗重症胰腺炎的应用效果确切,且大剂量乌司他丁可提高效果,可有效改善血气指标和降低炎症水平,改善临床症状,缩短疗程,且无严重不良反应,安全有效,值得推广应用。

Objective To explore the effect of routine drugs combined with ulinastatin in treatment of severe pancreatitis.Methods 90 patients with severe pancreatitis were retrospectively analyzed from June 2015 and June 2017 and they were divided into different groups according to random number table method.The control group(34 cases)was treated by single routine drug while the observation group(56 cases)was treated by routine drugs combined with ulinastatin.Among whom,they were divided into two groups according to the dosage of ulinastatin.The group A(30 cases)was given 100,000 units of ulinastatin and group B(26 cases)was given 400,000 units.The control rates of severe pancreatitis,the disappearance time of abdominal pain,time of reaching standard of amylase,total length of hospital stay,the serum amylase and inflammation index before and after intervention and adverse reaction rate of drugs were compared between two groups.Results The control rate of severe pancreatitis in the observation group was higher than that in the control group,and the treatment effect in group B was higher than that in group A,P<0.05.The disappearance time of abdominal pain,time of reaching standard of amylase and total length of hospital stay in the observation group were shorter than those in the control group,P<0.05.The serum amylase and inflammation indexes before intervention were similar between the two groups,P>0.05.After intervention,the serum amylase and inflammatory indexes in the observation group were better than those in the control group,P<0.05.The adverse reaction rates of drugs in the observation group the control group had no significant difference,P>0.05.Conclusion Routine drugs combined with ulinastatin have accurate effects in the treatment of severe pancreatitis,and large doses of ulinastatin can improve the effect.It can effectively improve the blood gas index,reduce the level of inflammation,improve the clinical symptoms and shorten the course of treatment.Also it has no serious adverse reactions and it is safe and effective,which is worthy of promotion and application.